Functional Sensitivity and Mutational Robustness of Proteins

Sensitivity and robustness appear to be contrasting concepts. However, natural proteins are robust enough to tolerate random mutations, meanwhile be susceptible enough to sense environmental signals. Both high functional sensitivity (i.e., plasticity) and mutational robustness are compatible. To analyze the protein dynamics under external perturbations and mutations, we introduce fluctuation…

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Source: bioRxiv
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