Evolutionary dynamics in Barrett oesophagus: implications for surveillance, risk stratification and therapy – Nature Reviews Gastroenterology & Hepatology
Cancer development is a dynamic evolutionary process. This Review explores the mechanisms underlying clonal expansion and contraction as well as the evolutionary dynamics in Barrett oesophagus and its progression to dysplasia and oesophageal adenocarcinoma. The implications for patient management (including surveillance, risk stratification and therapy) are also explored.
