ESTRO/EANO recommendation on reirradiation of glioblastoma
Reirradiation of brain tumors has a long history of preclinical and clinical studies especially with regards to effectiveness and safety in the recurrent setting. Clinical benefit for reirradiation of brain tumors with data from individual case series dates back more than 80 years [61]. In a recent systematic review by the European Society of Radiotherapy and Oncology (ESTRO) and the European Organization for Research and Treatment of Cancer (EORTC) of 439 studies conducted from 2000 to 2020 on reirradiation, 117 (24 %) involved the brain, and most of them included patients with high-grade gliomas [2].
