Objective To examine whether treatment with epigallocatechin gallate (EGCG) influences progression of brain atrophy, reduces clinical and further radiologic disease activity markers, and is safe in patients with progressive multiple sclerosis (PMS). Methods We enrolled 61 patients with primary or secondary PMS in a randomized double-blind, parallel-group, phase II trial on oral EGCG (up to 1,200…
A 58-year-old woman presented with 2 weeks of dizziness and unsteady gait. Examination revealed broad-based ataxic gait. Routine blood and CSF tests were normal. Brain…
The Without Borders section is looking for blogs on the topic of neurology and global health. The mission of the Without Borders section is to…
Dr. Justin Abbatemarco talks with Dr. Ellen Iacobaeus about patient characteristics, disease-modifying therapy, and disability progression in Swedish patients with late-onset MS and adult-onset MS…
Background and ObjectivesThe cognitive reserve hypothesis posits that cognitively stimulating work delays the onset of mild cognitive impairment (MCI) and dementia. However, the effect of…
Since the launch of OpenAI’s ChatGPT, the application of artificial intelligence (AI) in medical education has ignited a polarized discussion. Two main advancements will change…
Clinically available deep brain recordings in patients with Parkinson disease (PD) offer insights into disease mechanisms and create a pathway for personalized treatment strategies. This…
A 12-year-old girl born to third-degree consanguineous parents presented with 2 years of progressive dystonia starting in both lower limbs followed by upper limbs, along…
Background and ObjectivesThe purpose of this guideline is to update the 2010 American Academy of Neurology (AAN) brain death/death by neurologic criteria (BD/DNC) guideline for…
Background and ObjectivesThe time taken to achieve blood pressure (BP) control could be pivotal in the benefits of reducing BP in acute intracerebral hemorrhage (ICH).…
Background and ObjectivesPrevious studies have linked the MRI measures of perivascular spaces (PVSs), diffusivity along the perivascular spaces (DTI-ALPS), and free water (FW) to cerebral…
