Dual roles of the Arabidopsis PEAT complex in histone H2A deubiquitination and H4K5 acetylation
This study identifies the Arabidopsis ubiquitin-specific protease UBP5 as a major histone H2A deubiquitinase and demonstrates that it serves as a subunit of PEAT complex. The PWWP and EPCR components of the PEAT complex are involved in UBP5-mediated H2A deubiquitination and HAM1/2-mediated histone H4K5 acetylation, respectively, revealing dual roles of the PEAT complex in H2A deubiquitination and H4K5 acetylation.