Dr. Rona Yaeger: Adagrasib plus cetuximab in KRASG12C-mutated metastatic CRC
Read the paper here: https://doi.org/10.1158/2159-8290.CD-24-0217
Read the paper here: https://doi.org/10.1158/2159-8290.CD-24-0217
AbstractThe tumor microenvironment (TME) profoundly influences tumorigenesis, with gene expression in the breast TME capable of predicting clinical outcomes. The TME is complex and includes…
Knowing what symptoms to look for can help your doctor find cancer early when it’s most treatable.
Matthew Lunning, DO, FACP, discusses the use of CAR T-cell therapy lisocabtagene maraleucel in the second-line setting for patients with B-cell lymphoma.
Abstract. Serine metabolism plays a pivotal role in cancer, making it an appealing therapeutic target. Two recent studies published in Nature Metabolism and Science Translational…
Abstract. Gain-of-function mutations in the histone acetylation ‘reader’ ENL, found in AML and Wilms tumor, are known to drive condensate formation and gene activation in…
Domenica Lorusso, MD, PhD, presents the final overall survival data from the randomized open -label phase 2 trial of relacorilant, a selective glucocorticoid receptor modulator…
An abstract is unavailable.
An Overview of MOA, Clinical Data, and Dosing Considerations
TWEAK secreted by Th17 cells promotes EMT by binding to Fn14 on colorectal cancer cells, suggesting that blocking the TWEAK-Fn14 interaction may be a promising…
Summary: . Pathogenic shifts in the gut microbiota are part of the “ecological” alterations that accompany tumor progression and compromise immunosurveillance. The future management of…