Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses – Nature Immunology

Mutations in the RNA-binding proteins Roquin-1 or Regnase-1 cause systemic autoimmunity. Heissmeyer and colleagues show that Roquin-1 and Regnase-1 physically interact and thereby regulate CD4+ and CD8+ T cell metabolism and functionality.

Read the full article here

Related Articles