Cough-Variant Asthma: The Asthma Phenotype No One Coughs About
Cough-variant asthma (CVA) is an asthma phenotype in which the main symptom is chronic cough, without wheezing or dyspnea (1). First characterized in the 1970s (2), CVA has become more recognized and is responsible for 30% of chronic cough cases in China (3). In addition to influencing quality of life, up to half of patients with CVA go on to develop classic asthma with wheeze and dyspnea (4, 5). Currently, the molecular mechanisms behind CVA, how it differs from classic asthma, and the specific predisposi
