Conclusive demonstration of iatrogenic Alzheimer’s disease transmission in a model of stem cell transplantation
In a groundbreaking study, the corresponding author and colleagues uncover a transplantable form of Alzheimer’s disease (AD), challenging the existing understanding of the disease. Through preclinical experiments, they show that transplanting bone marrow cells harboring a mutant amyloid precursor protein can rapidly induce AD pathology in recipients. This significant finding highlights the potential for iatrogenic transmission in AD, suggesting the need for comprehensive genomic screening of donors in tissue, organ, and stem cell transplantations to prevent the inadvertent transfer of central nervous system diseases.