imageimageCircadian rhythms of macrophages are altered by conditions associated with the tumor microenvironment, including acidic pH. This may be responsible for the heterogeneity in circadian clock gene expression within the tumor-associated …
imageimageInteraction between neurotrophin-3 (NT-3) receptor TrkC and phosphatase PTPσ creates an excitatory synaptic organizing complex. Analysis of a new knock-in (KI) mouse model with disrupted…
imageimageThe systemic control of tissue fibrosis by metabolic organs remains poorly understood. This study identifies procollagen C-endopeptidase enhancer-1 (PCPE-1) as an adipokine released from brown…
The systemic regulation of metabolic dysfunction-associated liver disease remains poorly understood. In this issue, Hsiao et al (2024) identify PCPE-1 as a brown-adipose tissue-derived mediator…
imageimageCRISPR-based diagnostics have the potential to increase the accessibility of genotyping for pathogenic variants due to its fast and user-friendly nature which enables on-site testing…
imageimageBesides inflammation, metabolic dysregulation also contributes to sepsis lethality, offering therapeutic potential. This study shows that loss of hepatic HNF4α activity in sepsis disrupts PPARα-regulated…
imageimageMacrophages are important cellular reservoirs of chikungunya virus (CHIKV), but the viral and host determinants that facilitate infection of these cells by CHIKV are unclear.…
BACH1 is critical for tumor metastasis induced by the Keto diet.
BACH1 is critical for tumor metastasis induced by the Keto diet.
imageimageType I IFNs (IFN-I), critical cytokines for fighting viral infections, promote Mycobacterium tuberculosis pathogenesis by exacerbating cell death of human monocyte-derived macrophages (MDM) infected with…
imageimageThe ATP2B1 and ATP2A1 Ca2+ pumps are deregulated during SARS-CoV-2 infection, due to an impaired PI3K/Akt/FOXO3 pathway, which is antagonised by a small molecule promoting…
