Abatacept for myositis
Nature Reviews Rheumatology – In a phase III clinical trial of abatacept for idiopathic inflammatory myopathy, the primary endpoint was not met but the results suggest abatacept could have benefits…
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Management of a Proximal Femoral Central Physeal Bar in a 3-Year-Old Child Using a Novel Surgical Technique
We present a proximal femoral central physeal bar secondary to femoral neck fracture management, in a 3-year-old boy. He presented with progressive femoral neck deformity…
National Football League Quarterbacks With Ulnar Collateral Ligament Injuries Have High Return-to-Play Rates, but Older Players Have Inferior Postinjury Performance
To characterize the epidemiology, mechanism (contact vs noncontact), management, and return-to-play (RTP) times for quarterbacks in the National Football League (NFL) who experienced ulnar collateral…
Sleep and circadian rhythm disturbances as risk and… : PAIN Reports
known about the mechanisms underlying progression to multiple (more than 1) COPCs. This study aims to address the gap by investigating the role of common…
Experiencing pain: perspectives of Patrick D. Wall—founding … : PAIN
l pain nucleus. Rather, it is a complex “signature” of brain activity normally driven by sensory stimuli, but in the event of pathology also from…
Weathering the Cytokine Storm: Macrophage Activation Syndrome in Adults & Children – The Rheumatologist
Peter Nigrovic, MD, provides a practical guide to the diagnosis & treatment of macrophage activation syndrome (MAS) in children & adults.
European expert recommendations for managing systemic sclerosis and its complications
Nature Reviews Rheumatology – The updated 2023 EULAR recommendations for treatment of systemic sclerosis bring notable changes to recommendations for skin, peripheral vascular disease, interstitial…
Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans
Nature Communications – Osada et al. used MRI and brain stimulation to outline the macroscopic cerebral circuits for response inhibition: visual cortex→dorsal anterior insula→inferior…
Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate
Nature Communications – Androgen response elements (AREs) regulation produce opposite effects in normal and cancer prostate cells. Here, authors engineer a modifier of ARE-containing chromatin…
Shortening Dome Osteotomy for the Correction of Coronal Plane Elbow Deformities
Severe elbow deformities are common in developing countries because of neglect or as a result of prior treatment that achieved poor reduction. Various osteotomy techniques…
Weathering the Cytokine Storm: Macrophage Activation Syndrome in Adults & Children – The Rheumatologist
Peter Nigrovic, MD, provides a practical guide to the diagnosis & treatment of macrophage activation syndrome (MAS) in children & adults.