Crohn’s disease (CD) is a chronic inflammatory intestinal disease, with frequent aberrant healing and stricturing complications. Crosstalk between activated myeloid and stromal cells is critical in pathogenicity1,2 with increases in intravasating monocytes correlated to anti-TNF treatment non-response3. The highest effect risk alleles are loss-of-function NOD24,5 mutations, which increase risk…
Nature Aging – Tong et al. construct simulations using DNA methylation data to quantify what proportion of the predictive accuracy of epigenetic clocks could be…
Nature Genetics – The authors develop and harness a suite of epigenome editing tools to explore the role of different epigenetic marks in modulating transcription.…
Nature Reviews Psychology – Declines in adolescent mental health over the past decade have been attributed to social media, but the empirical evidence is mixed.…
Nature Communications – Here, the authors simulate COVID-19 outbreaks on an empirical contact network derived from digital contact data collected on cruise ships. They model…
Nature Aging – Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological…
Communications Biology – The article describes the greeting behaviour of elephants and provides an account of first-order intentionality and multicomponent signalling in an animal group…
Nature Genetics – The authors develop and harness a suite of epigenome editing tools to explore the role of different epigenetic marks in modulating transcription.…
Nature Communications – Plastics, chemical production, and fertilizers commonly rely on fossil fuels. Here the authors examine these uses in China and find that in…
Nature Communications – This study reports a quantitative tool for resource-based industries aimed at supporting sustainable, low-carbon regional transitions. The results provide optimal transition…
Nature Communications – When countries phase out coal, they compensate affected companies, communities and workers. Today more than $200 billion are allocated for such payoff,…
