A caution against KRAS-guided margin width during hepatectomy for colorectal liver metastases
In this issue of Surgery, Rhaiem et al characterized the association of R0 or R1 margins with outcomes for patients undergoing hepatectomy for KRAS wild-type (KRAS-wt) and mutated (KRAS-mut) colorectal liver metastases (CLM) between 2010 to 2015.1 Among 593 patients included in this retrospective study from 9 institutions across multiple countries, 71% were KRAS-wt. There were no differences in most patient characteristics based on KRAS status. R1 resection, defined as the presence of tumor cells within 1 mm of the resection margin or the presence of microscopic residual disease, was reported in 32.7% of patients overall, with no difference across KRAS status.