The Cancer Plus Daily
A selection of articles, blog posts, videos and photos recommended by Wafik El-Deiry MDPhD
A selection of articles, blog posts, videos and photos recommended by Wafik El-Deiry MDPhD
Nature Communications – Polypharmacology drugs are compounds designed to inhibit multiple protein targets. Here, authors use recent advances in AI to rapidly generate polypharmacology compounds…
Li et al. perform comprehensive multi-omics characterization of a broad range of renal cell carcinomas, improving our understanding of the biology, proteogenomics, post-translational modifications, and metabolism…
Peering into a biological cell reveals a bustling microscopic world. The workhorses within this realm are specialized structures called organelles that perform vital cellular functions.…
“You know that new sound you’re lookin’ for? Well listen to this!” Marty McFly’s entire future rests on being able to play the guitar at…
In a first-ever human clinical trial of four adult patients, an mRNA cancer vaccine developed at the University of Florida quickly reprogrammed the immune system…
Systemically administered mRNA aggregates (RNA-LPA) transfect lymphoreticular organs, inducing a massive cytokine/chemokine response that rapidly reprograms the tumor microenvironment while mobilizing dendritic cells/lymphocytes to elicit…
Cells carrying a monoallelic germline BRCA2 mutation can bypass Knudson’s “two-hit” requirement to initiate tumorigenesis when the glycolytic metabolite methylglyoxal transiently disables BRCA2 function. Metabolic…
Tourists delighted as pinnipeds congregate at city’s Pier 39, apparently attracted by feast of anchovies
Cities are frustrated by 911 calls from senior facilities to help residents off the floor or toilet. Some are now charging fees, but facilities keep…
When the U.S. government’s spending bills for this fiscal year were belatedly finalized in March, the U.S. National Institutes of Health (NIH) largely escaped the…