Mitochondrial fatty acid oxidation drives senescence
Nuclear DNA damage activates fatty acid–fueled mitochondrial energy metabolism to induce cellular senescence, a hallmark of aging.
Related Articles
Chronic myelomonocytic leukemia: molecular pathogenesis and therapeutic innovations
Chronic myelomonocytic leukemia (CMML) is an aggressive clonal stem cell disorder categorized amongst myelodysplastic/myeloproliferative (MDS/MPN) overlap neoplasms. While sharing features with both MDS and MPN,…
‘It is beyond broken now’ – inside our terrifying NHS crisis – Liverpool Echo
Special report: Patients waiting in ambulances for 24 hours, exhausted and desperate staff feeling helpless and a health service now on life support
Demi Moore wins first-ever acting award for ‘The Substance’: Read her Golden Globes speech
Moore brought a jolt of emotional energy to the room with a speech that touched on her own career in the face of playing an…
The Italian health data system is broken
The population of Italy is projected to decrease by approximately 8% by 2050, falling from 59 million in 2022 to 54.4 million, due to increased…
Welcome! You are invited to join a webinar: IACH Webinar- Pioneers in Hematology: Dr Thierry Facon. After registering, you will receive a confirmation email about joining the webinar.
The IACH is thrilled to invite you to join us on an enlightening journey through the evolution of hematology. In this exclusive webinar series, we…
2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | Circulation
Aim: The “2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery” provides recommendations to guide clinicians in the perioperative cardiovascular evaluation and management of…
Keir Starmer: I will not let our NHS die — this is my prescription
This new year I am resolved to reverse the decline and make the health service fit for the future
Is emergency doctors’ tolerance of clinical uncertainty on a novel measure associated with doctor well-being, healthcare resource use and patient outcomes?
Introduction Emergency doctors routinely face uncertainty—they work with limited patient information, under tight time constraints and receive minimal post-discharge feedback. While higher uncertainty tolerance (UT)…
The mythbuster: The five management books NHS leaders must read
Steve Black recommends his top five books on policy and strategy for healthcare leaders