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Mashup Score: 1A cellular mechanism contributing to pain-induced analgesia : PAIN - 57 minute(s) ago
ll types in the ACC and how this contributes to sensory sensitization is not completely understood. This study confirms the existence of 2 primary subtypes of pyramidal neurons in layer 5 of the rostral, agranular ACC, which we could classify as intratelencephalic (IT) and cortico-subcortical (SC) projecting neurons, similar to other cortical brain areas. Through retrograde labeling, whole-cell patch-clamp recording, and morphological analysis, we thoroughly characterized their different electrophysiological and morphological properties. When examining the effects of peripheral inflammatory pain on these neuronal subtypes, we observed time-dependent plastic changes in excitability. During the acute phase, both subtypes exhibited reduced excitability, which normalized to pre-inflammatory levels after day 7. Daily conditioning with nociceptive stimuli during this period induced an increase in excitability specifically in SC neurons, which was correlated with a decrease in mechanical sens
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 0The Role of Urologists in Managing De Novo Metastatic Prostate Cancer - Benjamin Lowentritt - 57 minute(s) ago
Alicia Morgans engages in a discussion with Benjamin Lowentritt, focusing on comprehensive care for prostate cancer patients, particularly those with de novo metastatic hormone-sensitive disease. Dr. Lowentritt shares a patient case illustrating the challenges and strategies in managing such cases over time. They emphasize the importance of multidisciplinary teams and seamless communication…
Source: www.urotoday.comCategories: General Medicine News, General NewsTweet-
The role of urologists in managing de novo metastatic #ProstateCancer. @UroDrBen @ChesUrology and @CaPsurvivorship @DanaFarber emphasize the importance of multidisciplinary teams and seamless communication between urologists and medical oncologists > https://t.co/Fw7WaPSATK https://t.co/jOiCIf9PN4
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Mashup Score: 0New Data Help Predict Extended Survival After IDH Inhibitors for IDH1-, IDH2-Mutated AML | Blood Cancers Today - 57 minute(s) ago
MDS-related gene mutations did not correlate with worse outcomes, though evaluation of other factors in survival prediction would require a larger study.
Source: bloodcancerstoday.comCategories: General Medicine News, Oncologists1Tweet-
📊 A study led by Nilesh Kapoor, MD, of @UTSWMedCenter, aimed to pinpoint the clinical characteristics of elderly patients with IDH1– or IDH2-mutated #AML who had survival of two years or longer after IDHi therapy. 📰 Read more: https://t.co/5AV1RphsJg https://t.co/e4V34oBTE2
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Experts in multiple myeloma discussed real-world efficacy and safety data associated with the use of GPRC5D-targeting bispecific agents to treat patients with R/R multiple myeloma.
Source: www.cancernetwork.comCategories: General Medicine News, Oncologists1Tweet-
Experts in multiple myeloma discussed real-world efficacy and safety data associated with the use of GPRC5D-targeting bispecific agents to treat patients with R/R multiple myeloma. #mmsm https://t.co/dtHiSv0Pze
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Mashup Score: 0Extension of the PRISMA 2020 statement for living systematic reviews (PRISMA-LSR): checklist and explanation - 58 minute(s) ago
Publications of living systematic reviews (LSRs) are increasing rapidly. Guidance facilitating transparent, complete, and accurate reporting of LSRs is needed. This paper reports the development of an extension of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 statement for LSRs (PRISMA-LSR). The PRISMA-LSR extension includes the PRISMA-LSR checklist, the PRISMA-LSR flow diagram, reporting recommendations for the LSR status, and an explanation and elaboration document. This extension has been developed as an “add-on” to the PRISMA 2020 statement, meaning it should be used in addition to the PRISMA 2020 statement. The PRISMA-LSR extension is expected to benefit authors, editors, peer reviewers, and users of LSRs through transparent, complete, and accurate reporting of LSRs. Living systematic reviews (LSRs) are attracting attention from researchers and medical journals.12 Between 2014 (when the LSR approach first emerged3) and 2019, the rate of publi
Source: www.bmj.comCategories: General Medicine News, General HCPsTweet-
Publications of living systematic reviews are increasing rapidly. This paper reports the extension of the PRISMA 2020 statement for living systematic reviews, with a checklist and explanations https://t.co/6G14TnjKYV
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Mashup Score: 0Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study - 58 minute(s) ago
Read the full article here
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Our findings are consistent with other published literature supporting a role for choline metabolism in diabetes. Our study extends the current literature by analyzing a racially diverse population-based cohort of early middle-aged individuals in whom preventive activities may be most relevant.
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Mashup Score: 0Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study - PubMed - 59 minute(s) ago
Our findings are consistent with other published literature supporting a role for choline metabolism in diabetes. Our study extends the current literature by analyzing a racially diverse population-based cohort of early middle-aged individuals in whom preventive activities may be most relevant.
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Partners & KOLsTweet-
Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk D… https://t.co/BKIRdHlQ6R
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Mashup Score: 0UK reports decade-low levels of antibiotic sales, resistance on farms - 60 minute(s) ago
Sales of antibiotics for use in food-producing animals in the United Kingdom have fallen by 59% since 2014, according to the latest UK-VARSS report.
Source: www.cidrap.umn.eduCategories: General Medicine News, Infectious DiseaseTweet-
UK reports decade-low levels of antibiotic sales, resistance on farms Sales of antibiotics for use in food-producing animals in the United Kingdom have fallen by 59% since 2014, according to the latest UK-VARSS report. https://t.co/Rkdon7vdPi https://t.co/lZgsgmoZw1
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Mashup Score: 0
Though hospital performance has remained relatively stable, high labor costs continue to challenge hospitals’ bottom line, according to September figures from Kaufman Hall. | Labor expenses from providers accounted for 84% of medical groups’ total expenses. The median subsidy per employed physician was $304,312, rising above $300,000 for the first time. This increase underscores the unsustainable nature of traditional employment models, Kaufman Hall said.
Source: www.fiercehealthcare.comCategories: General Medicine News, General HCPsTweet-
Kaufman Hall: Performance stable, but high labor costs challenge hospitals https://t.co/idPrP8zlwA
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Mashup Score: 7
Deepak Bhatt, MD, MPH, MBA, spoke to Cardiovascular Business about the growing importance of evaluating coronary inflammation in heart patients. There has been an explosion of interest in this area since the FDA’s 2023 clearance of colchicine.
Source: cardiovascularbusiness.comCategories: General Medicine News, CardiologistsTweet-
Cardiologist examines the latest breakthroughs in coronary inflammation research https://t.co/GHk7IeG7wx
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Now in #PAIN: “A cellular mechanism contributing to pain-induced analgesia” by Franciosa et al. https://t.co/hSAEDVx37p https://t.co/PaHq0AdDsc