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Mashup Score: 0
Phaeochromocytomas and paragangliomas (PPGLs) release catecholamines leading to catecholamine-induced hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg. CIH crises can be complicated by tachyarrhythmias, hypotension, or life-threatening target organ damage while treatment remains undefined, often requiring co-management between endocrinologists and cardiologists. Furthermore, biochemical diagnosis of a PPGL as a cause of a CIH crisis can be difficult to identify or confounded by comorbid conditions, potentially resulting in misdiagnosis.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 0Glycaemic index as part of the diabetes prevention strategy - 6 hour(s) ago
The study by Victoria Miller and colleagues1 in The Lancet Diabetes & Endocrinology adds to and extends the growing body of evidence of the importance of understanding the physiological effect of dietary carbohydrate on homeostatic systems as a driver for the risk of non-communicable diseases (NCDs); for example, prevention of type 2 diabetes. Miller and colleagues use the glycaemic index and glycaemic load as a measure of the postprandial effect of dietary carbohydrate on blood glucose and how this affects the development of type 2 diabetes in the PURE cohort.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 0
Diets with a high glycaemic index and a high glycaemic load were associated with a higher risk of incident type 2 diabetes in a multinational cohort spanning five continents. Our findings suggest that consuming low glycaemic index and low glycaemic load diets might prevent the development of type 2 diabetes.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 0How clinically relevant is statin-induced diabetes? - 7 hour(s) ago
Diabetes is a common chronic disease that affects up to 10% of adults worldwide.1 People with diabetes are at high risk for a wide variety of serious health consequences including, but not limited to, myocardial infarctions, strokes, heart failure, blindness, kidney failure, lower limb amputations, cognitive impairment, and many cancers. This increased risk is independent of other risk factors, is causally related to increased plasma glucose concentrations for cardiovascular events and some of the other consequences,2,3 and doubles the risk of all-cause death.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 15Bone mineral density as a surrogate endpoint for fracture risk reduction in clinical trials of osteoporosis therapies: an update on SABRE - 23 hour(s) ago
Launched as a public–private partnership funded by the Foundation for the National Institutes of Health, the Study to Advance Bone Mineral Density as a Regulatory Endpoint (SABRE) aims to change the framework for how clinical trials of new anti-osteoporosis drugs are conducted, to promote innovation in the field of osteoporosis, where underdiagnosis and undertreatment of disease have been deemed a crisis.1 Osteoporosis-related fractures, which lead to high morbidity and increased mortality, are a large and growing public health concern as one in two women and one in five men over the age of 50 years will have a fracture.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 22Effect of population-wide screening for presymptomatic early-stage type 1 diabetes on paediatric clinical care - 1 day(s) ago
Population-wide screening of children for presymptomatic early-stage type 1 diabetes is gaining momentum. Studies have demonstrated feasibility and acceptance, and shown that the rate of progression to clinical stage 3 diabetes is similar if islet autoantibody-positive early-stage type 1 diabetes is identified from general population or first-degree relative screening.1,2 Moreover, in conjunction with an education and follow-up package, screening significantly reduces the rates of ketoacidosis, symptoms, and hospitalisation.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 111
Tackling the mechanisms underlying ageing is desirable to help to extend the duration and improve the quality of life. Life extension has been achieved in animal models by suppressing the growth hormone–insulin-like growth factor 1 (IGF-1) axis and also via dietary restriction. Metformin has become the focus of increased interest as a possible anti-ageing drug. There is some overlap in the postulated mechanisms of how these three approaches could produce anti-ageing effects, with convergence on common downstream pathways.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 36
Type 1 diabetes is around twice as common in the offspring of men with type 1 diabetes than in the offspring of women with type 1 diabetes, but the reasons for this difference are unclear. This Review summarises the evidence on the rate of transmission of type 1 diabetes to the offspring of affected fathers compared with affected mothers. The findings of nine major studies are presented, describing the magnitude of the effect observed and the relative strengths and weaknesses of these studies. This Review also explores possible underlying mechanisms for this effect, such as genetic mechanisms (eg, the selective loss of fetuses with high-risk genes in mothers with type 1 diabetes, preferential transmission of susceptibility genes from fathers, and parent-of-origin effects influencing gene expression), environmental exposures (eg, exposure to maternal hyperglycaemia, exogenous insulin exposure, and transplacental antibody transfer), and maternal microchimerism.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 0Demarcating the benefits of hybrid closed loop therapy in pregnant women with type 1 diabetes - 1 day(s) ago
The role of hybrid closed-loop systems in the clinical management of type 1 diabetes is rapidly expanding. Randomised controlled trials have shown life-changing clinical and quality-of-life benefits beyond those that can be obtained by use of continuous glucose monitoring (CGM) with an insulin pump or multiple daily injection therapy.1 Meta-analyses of trial data confirm substantial glycaemic improvements in people of all ages, with 8–12 percentage points higher time spent in the target glucose range of 3·9–10·0 mmol/L, and lower mean glucose with less or no additional hypoglycaemia.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 16
In pregnant women starting with tighter glycaemic control, AHCL therapy did not improve overall time in target range but improved overnight time in target range, reduced time below range, and improved treatment satisfaction. These data suggest that the MiniMed 780G can be safely used in pregnancy and provides some additional benefits compared with standard insulin therapy; however, it will be important to refine the algorithm to better align with pregnancy requirements.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
#Catecholamine-induced #hypertensive crises: current insights and management https://t.co/mxR0zSteeM #phaeochromocytomas #paragangliomas #PPGLs