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Mashup Score: 53Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression - 14 hour(s) ago
Infiltrating immune cells are important contributors to tissue fibrosis. Here, Liang et al. reveal that intestinal ILC3s migrate to the kidney via CXCR6/CXCL16 during renal fibrosis. Within the kidney, immigrated ILC3s express PD-1, which regulates IL-23 receptor endocytosis and enhances IL-17A production, thus exacerbating the fibrotic niche.
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Mashup Score: 43Breadth of Fc-mediated effector function correlates with clinical immunity following human malaria challenge - 6 day(s) ago
Malaria vaccine development targeting blood-stage infections requires a correlate of protection. Nkumama et al. leverage a controlled human malaria infection model to study mechanisms of acquired immunity. They show that the breadth of IgG Fc-mediated effector functions targeting merozoites and rings is the strongest predictor of protection and is superior to GIA. These findings present important considerations for vaccine development.
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Mashup Score: 21
In contrast to other immune cell lineages, little is known about how eosinophils develop, expand, and mature in health and disease. Using single-cell RNA sequencing, high-dimension flow cytometric screening, and IL-5Rα reporter mice, Jorssen, Van Hulst, et al. resolve eosinophilopoiesis and show that the therapeutic target, cytokine IL-5, promotes the expansion but not the maturation of eosinophil progenitors.
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Mashup Score: 190Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation - 8 day(s) ago
How immune and epithelial cells simultaneously fuel their dysfunction in chronic skin diseases is unclear. Subudhi and Konieczny et al. find that IL-17-induced epithelial HIF1α activates glycolysis, which potentiates the γδ T17 response via lactate. This metabolic circuit drives multisystems pathology and can be targeted in inflammatory disease.
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Mashup Score: 84
In contrast to other immune cell lineages, little is known about how eosinophils develop, expand, and mature in health and disease. Using single-cell RNA sequencing, high-dimension flow cytometric screening, and IL-5Rα reporter mice, Jorssen, Van Hulst, et al. resolve eosinophilopoiesis and show that the therapeutic target, cytokine IL-5, promotes the expansion but not the maturation of eosinophil progenitors.
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Mashup Score: 120The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects - 9 day(s) ago
Steady-state antigen recognition triggers tolerant CD8+ T cell states that restrain autoimmunity and limit anti-cancer immunity. The relationship between tolerant states and other differentiation states remains unclear. Van Der Byl et al. demonstrate that tolerance triggers a transcriptionally and epigenetically distinct differentiation trajectory. The synergistic actions of strong TCR signaling and inflammation are required to override the tolerance checkpoint.
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Mashup Score: 49Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance - 9 day(s) ago
Obesity induces ILC2 dysfunction in adipose tissue and insulin resistance by undetermined mechanisms. Here, Sun et al. show that liver kinase B1 (LKB1) signaling protects ILC2s from mitophagy by suppressing PD-1 expression. Moreover, PD-1 blockade restores ILC2 function and reverses obesity-associated insulin resistance.
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Mashup Score: 167Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation - 10 day(s) ago
How immune and epithelial cells simultaneously fuel their dysfunction in chronic skin diseases is unclear. Subudhi and Konieczny et al. find that IL-17-induced epithelial HIF1α activates glycolysis, which potentiates the γδ T17 response via lactate. This metabolic circuit drives multisystems pathology and can be targeted in inflammatory disease.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 41Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation - 10 day(s) ago
Cellular and molecular mechanisms leading to SLE are unclear. Li et al. show that SLE CD4+ T cells downregulate CBLs and ablation of CBLs in mouse T cells causes hyper Tfh cell responses and SLE. CBLs restrain Tfh cell responses by ubiquitinating ICOS, consequently facilitating BCL6 degradation via CMA.
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Mashup Score: 181Classical monocyte ontogeny dictates their functions and fates as tissue macrophages - 10 day(s) ago
Classical monocytes present as a circulating and heterogenous macrophage precursor pool, but the implication for tissue macrophage biology remains elusive. Trzebanski et al. establish that the hematopoietic origin of monocytes dictates their homing and differentiation potential in select peripheral tissues.
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