Wilson disease in the USA: epidemiology and real-world patient characteristics based on a retrospective observational health claims study
Objectives To describe the epidemiology, patient characteristics and comorbidities in patients with Wilson disease (WD) in the USA. Design Retrospective, population-based study. Setting The study used the US Komodo claims database containing records regarding medical claims for over 120 million individuals. Participants Patients with WD were identified via ICD-10 (10th revision of the International Classification of Diseases) code during the study period 2016–2019 and no age restriction was applied. A further stratification by disease subtype (‘hepatic’, ‘neurologic’ and ‘psychiatric’) was performed. Main outcome measures WD prevalence was reported by age, sex and US census regions/divisions. Adjusted prevalence was calculated using age-specific prevalence standardised to the USA (2010 US census) and to the world (WHO 2000–2025) to enable comparisons across countries, using direct standardisation of prevalence estimates by age group. Results Overall, 2115 patients with WD were identifi
