Vaginal progesterone does not prevent recurrent preterm birth in women with a singleton gestation, a history of spontaneous preterm birth, and a midtrimester cervical length >25 mm
We recently reported the results of a systematic review and meta-analysis that addressed the clinical question of whether vaginal progesterone is effective in preventing recurrent preterm birth and adverse perinatal outcomes in women with a singleton gestation and a history of spontaneous preterm birth.1 The results were conflicting. Although the administration of vaginal progesterone was…