Vaginal progesterone does not prevent recurrent preterm birth in women with a singleton gestation, a history of spontaneous preterm birth, and a midtrimester cervical length >25 mm

We recently reported the results of a systematic review and meta-analysis that addressed the clinical question of whether vaginal progesterone is effective in preventing recurrent preterm birth and adverse perinatal outcomes in women with a singleton gestation and a history of spontaneous preterm birth.1 The results were conflicting. Although the administration of vaginal progesterone was…

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