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Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice

Science Translational Medicine - As an alternative to ileocolonoscopy with biopsy required to diagnose and monitor inflammatory bowel diseases, Fournier et al . investigated the use of magnetic resonance imaging with microsized particles of iron oxide targeting mucosal vascular addressin cell adhesion molecule 1 on inflamed mucosal tissues. They showed that the contrast agent bound to activated endothelium in the...

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