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Mashup Score: 1
Patients with severe COVID-19 have a hyperinflammatory immune response suggestive of macrophage activation. Bruton tyrosine kinase (BTK) regulates macrophage signaling and activation. Acalabrutinib, a selective BTK inhibitor, was administered off-label to 19 patients hospitalized with severe COVID-19 (11 on supplemental oxygen; 8 on mechanical ventilation), 18 of whom had increasing oxygen…
Source: Science ImmunologyCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications - 4 year(s) ago
Wright et al. identify seven genetic subtypes of diffuse large B cell lymphoma (DLBCL) with distinct outcomes and therapeutic vulnerabilities. The LymphGen probabilistic classification tool that can classify a DLBCL biopsy into the genetic subtypes is developed, which could be used for precision medicine trials.
Source: Cancer CellCategories: Hem/Oncs, Latest HeadlinesTweet-
The Staudt lab has updated the classification of DLBCL with new categories and the LymphGen algortihm is available on a public server! A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications https://t.co/e2cWLcDEJm
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Inhibition of Bruton tyrosine kinase in patients with severe COVID-19 https://t.co/pksLdAbO50