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Mashup Score: 2The RNA helicase DDX21 activates YAP to promote tumorigenesis and is transcriptionally upregulated by β-catenin in colorectal cancer - 2 month(s) ago
Oncogene – The RNA helicase DDX21 activates YAP to promote tumorigenesis and is transcriptionally upregulated by β-catenin in colorectal cancer
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 4
Oncogene – Jumonji histone demethylases are therapeutic targets in small cell lung cancer
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet-
New #OpenAccess study from @EMartinezLab highlights the translational potential of Jumonji KDM inhibitors against small cell lung cancer. https://t.co/jrGg6ZDupw #LungCancer #CancerResearch #SCLC
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Mashup Score: 6PrPC controls epithelial-to-mesenchymal transition in EGFR-mutated NSCLC: implications for TKI resistance and patient follow-up - 3 month(s) ago
Oncogene – PrPC controls epithelial-to-mesenchymal transition in EGFR-mutated NSCLC: implications for TKI resistance and patient follow-up
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet-
Increased expression of PrPC in EGFR-mutated #NSCLC promotes EMT and resistance to EGFR tyrosine kinase inhibitors - could circulating PrPC be a novel biomarker to monitor lung cancer evolution? https://t.co/blMLbIG3NJ @SophieMouillet @Sorbonne_Univ_
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Mashup Score: 2GLI1 confers resistance to PARP inhibitors by activating the DNA damage repair pathway - 3 month(s) ago
Oncogene – GLI1 confers resistance to PARP inhibitors by activating the DNA damage repair pathway
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet-
Could GLI1 inhibitors be effective in the treatment of #BRCA1-deficient tumours? You can read more about the role of GLI1 in enhancing the DNA damage repair capacity here: https://t.co/aRnSY6otxi
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Mashup Score: 5Normalization of Snai1-mediated vessel dysfunction increases drug response in cancer - 3 month(s) ago
Oncogene – Normalization of Snai1-mediated vessel dysfunction increases drug response in cancer
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet-
Targeting Snai1 in the tumour endothelium increases drug response and reduces #metastasis. 🔬https://t.co/rEOsZXa6SR @erik__henke #OpenAccess
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Mashup Score: 0NNMT switches the proangiogenic phenotype of cancer-associated fibroblasts via epigenetically regulating ETS2/VEGFA axis - 3 month(s) ago
Oncogene – NNMT switches the proangiogenic phenotype of cancer-associated fibroblasts via epigenetically regulating ETS2/VEGFA axis
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet-
How can #cancer-associated fibroblast facilitate angiogenesis in the #tumor microenvironment? Read more to find out! 🔗 https://t.co/r7ANdPW09F
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Mashup Score: 2Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks - 4 month(s) ago
Oncogene – Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet-
A new article published provides a mechanistic understanding of the favorable responses to PARPis in SLFN11-expressing and BRCA-deficient #ovarian tumours. Read more | https://t.co/z5CaoPLa1D
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Mashup Score: 6Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer - 4 month(s) ago
Oncogene – Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet-
The patient-derived organoid models reveal #trascriptional invasion signature with prognostic potential in #headandneck cancer! 📖 Read more > https://t.co/fLZC3mv6q2
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Mashup Score: 4N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance - 4 month(s) ago
Oncogene – N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance
Source: www.nature.comCategories: General Medicine News, Oncologists1Tweet-
A new study identifying a potential avenue to mitigate #PDAC gemcitabine resistance by targeting TGFB2 and lipid metabolism. https://t.co/6yTKx2sWjH
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Mashup Score: 2Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation - 5 month(s) ago
Oncogene – Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation
Source: www.nature.comCategories: General Medicine News, Onc News and JournalsTweet-
Could tumour-resident microbiota be a potential target for preventing and treating #ColorectalCancer liver metastasis? 👉https://t.co/31fjKZlVT7 #OpenAccess
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Read more about how β-catenin transcriptionally activates DDX21 in #CRC and how YAP/TEAD is activated in response to ribosomal stress, underscoring the combination #therapy targeting the nucleolar DDX21 and YAP. 📖 https://t.co/fqY4e57Xrd