Between 2% to 3% of all patients and 5% to 6% of all women who present with what looks like an acute coronary syndrome (ACS) are actually suffering from a peculiar and reversible acute cardiac condition, not caused by epicardial coronary obstruction, called takotsubo syndrome (TTS). TTS, also known as takotsubo cardiomyopathy, stress cardiomyopathy and “broken heart syndrome,” is a reversible form of left ventricular (LV) dysfunction first recognized in Japan in 1990. 1 The name “takotsubo” originates