-
Mashup Score: 18Comparable outcomes of outpatient remdesivir and sotrovimab among high-risk patients with mild to moderate COVID-19 during the omicron BA.1 surge - 2 month(s) ago
Scientific Reports – Comparable outcomes of outpatient remdesivir and sotrovimab among high-risk patients with mild to moderate COVID-19 during the omicron BA.1 surge
Source: www.nature.comCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 28
AbstractBackground. Nocardia tends to cause infection in immunocompromised patients or those with chronic pulmonary disease. Nocardia is known to recur, prompti
Source: academic.oup.comCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 30
Background Men who have sex with men (MSM) and persons living with human immunodeficiency virus (PLWH) were disproportionately affected by global mpox outbreak …
Source: journals.sagepub.comCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 41
Abstract. Background: Periprosthetic joint infection (PJI) following total joint arthroplasty is a serious complication associated with significant morbidity. While Gram-positive cocci are the predominant causative organisms, PJIs caused by rapidly growing mycobacteria (RGM) have been reported, albeit at a lower frequency. This study aimed to investigate the characteristics and management of PJI caused by RGM. Methods: A retrospective review was conducted using an institutional PJI database to identify patients diagnosed with PJI due to RGM from January 2010 to December 2021. Clinical data, including demographics, symptoms, comorbidity information, laboratory parameters, surgical procedures, medical treatment and outcomes, were collected and analyzed. Results: A total of eight patients were identified with PJI caused by RGM during the study period. The median age was 66 years old, and most cases occurred in patients with total knee arthroplasty (n=6). The isolated RGM species included
Source: jbji.copernicus.orgCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 22Antimicrobial susceptibilities of Campylobacter fetus: report from a reference laboratory | Journal of Clinical Microbiology - 2 month(s) ago
Our findings contribute to the scant literature on Campylobacter fetus antimicrobial susceptibility test results. We used a reference test method of agar dilution and provide MICs for a large number of organisms and antimicrobial agents.
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 31Impact of hypoalbuminemia on clinical outcomes among patients with obesity treated with ceftriaxone | Antimicrobial Agents and Chemotherapy - 2 month(s) ago
Ceftriaxone is a highly protein-bound antibiotic that exhibits concentration-dependent binding site saturation at higher doses (1, 2). Low serum albumin impacts the pharmacokinetics of ceftriaxone by increasing the unbound fraction of the drug, thereby increasing the volume of distribution (3). Only the fraction of the drug not bound to plasma proteins can distribute outside of the plasma and eventually be cleared from the body. Hypoalbuminemia has therefore been hypothesized to lead to suboptimal drug exposure over the dosing interval due to increased volume of distribution and increased drug clearance (3, 4). Conversely, pharmacologists have endorsed that in the setting of hypoalbuminemia, the bound and hence total drug concentration decreases, while free/unbound concentration remains unchanged (5). Hypoalbuminemia has previously been shown to decrease the probability of target attainment with ceftriaxone intermittent dosing by as much as 20% (6).
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 56
Rhodococcus species are facultative-intracellular, Gram-positive rods that closely resemble Nocardia and Mycobacterium species (1). The highest burden of these organisms is found in the soil, water, and manure of grazing animals (2). Rhodococcus equi/hoagii (herein referred to as R. equi) underwent a recent taxonomic modification to R. hoagii to simplify the identification of species (due to a prior heterotypic synonym of Corynebacterium hoagii) (3, 4). R. equi is a zoonotic human pathogen that can be acquired via inhalation or local inoculation. Significant pulmonary and extrapulmonary diseases due to R. equi have been described predominantly among immunocompromised patients (85% of cases), particularly those with HIV infection (5) and solid organ or hematopoietic stem cell transplantation (SOT or HSCT) (6, 7), but rarely also in immunocompetent hosts (8). Pulmonary infection is frequently associated with cavitary upper-lobar pneumonia (PNA), which in combination with weak acid-fast s
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 5World's Best Hospitals 2024 - 2 month(s) ago
Newsweek has partnered with Statista for its annual ranking of the world’s best hospitals, a series that began in March 2019. This year, the list includes data on 2,400 hospitals across 30 countries.
Source: www.newsweek.comCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 29Temporal trends in antifungal susceptibility of Cryptococcus neoformans isolates from a reference laboratory in the United States, 2011–2021 - 3 month(s) ago
Background There are no established clinical breakpoints for antifungal agents against Cryptococcus species; however, epidemiological cut-off values can help distinguish wild-type (WT) isolates with…
Source: onlinelibrary.wiley.comCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 13Infectious Diseases Practice Updates 2024 | Mayo Clinic School of Continuous Professional Development | CME Course Conference - 3 month(s) ago
February 19 – 23, 2024 – Royal Sonesta Kaua’i Resort – Lihue, Hawaii This course offers Live (in-person) and Livestream (virtual) attendance options. This interactive course provides practical updates on common topics and challenges faced with infectious diseases and key information on the application of new developments in the field. Information is delivered by subject matter
Source: ce.mayo.eduCategories: General Medicine News, Infectious DiseaseTweet
Publication Alert Is there any difference in the outcomes of covid-19 treated with remdesivir or a monoclonal antibody? This paper provides data on outcomes during the early phase of Omicron period when sotrovimab was active against the variants. https://t.co/p81Znqcutt