• Mashup Score: 7

    About Gabrielle Gabrielle Rich Aouad grew up in Switzerland where she graduated from Aiglon School. She graduated with honors from Oxford University in England, earning her B.A. in philosophy and modern languages. Fluent in five languages, Gabrielle was a champion skier, an expert in horseback riding and a skilled rock mountain climber. In the summer of 1991, she moved to…

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    • Congratulations @FerrellLabVUMC (Brent Ferrell) @VUMC_Medicine @VUMC_Cancer @VUMCHemOnc for your award from Gabrielle's Angel Foundation. For the inspiring story, check here: https://t.co/glipH2YDIY

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    Tumours employ various tactics to adapt and eventually resist immune attack. These mechanisms are collectively called adaptive immune resistance (AIR). The first defined and therapeutically validated AIR mechanism is the selective induction of programmed cell death 1 ligand 1 (PDL1) by interferon-γ in the tumour. Blockade of PDL1 binding to its receptor PD1 by antibodies (anti-PD therapy) has…

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    • The definitive review of Adaptive Immune Resistance at the tumor site by @TaeKonKim1 @VUMC_Cancer @VUMCHemOnc : Great work. https://t.co/GM054622EJ. .

  • Mashup Score: 9

    PURPOSE To provide guidance on exercise, diet, and weight management during active cancer treatment in adults. METHODS A systematic review of the literature identified systematic reviews and randomized controlled trials evaluating the impact of aerobic and resistance exercise, specific diets and foods, and intentional weight loss and avoidance of weight gain in adults during cancer treatment, on…

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    • Thank you @ASCO for some science based guidance on a topic that is important to all of us and very frequently asked about by the people we see in clinic. Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline https://t.co/gAE0cd36cO

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    Data culled from NASA’s New Horizons spacecraft’s journey past Pluto in 2015 have been further analyzed, revealing that much of Pluto’s bumpy landscape got covered in ice via a process known as cryovolcanism. The report, published in Nature Communications, pinpoints many of the planet’s massive ice volcanoes that may still remain active.

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    • Pluto's uneven surface caused by volcanoes https://t.co/X3wfWSWD9h Science is cool. My favorite dwarf planet

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    The development of immune-checkpoint inhibitors (ICIs) has heralded a new era in cancer treatment, enabling the possibility of long-term survival in patients with metastatic disease, and providing new therapeutic indications in earlier-stage settings. As such, characterizing the long-term implicatio …

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    • Great article from @VUMC_Cancer @VUMCHemOnc members Doug Johnson, @cnebhan and @JustinBalko Immune-checkpoint inhibitors: long-term implications of toxicity https://t.co/RTjBnS25LF

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    Edward Lynn Kaplan and Paul Meier worked separately analysing survival time data, both as graduate students at Princeton University and after graduation.1 In 1954, they independently submitted manuscripts to the Journal of the American Statistical Association, at which time John Tukey, their PhD mentor at Princeton and the journal’s editor, convinced them to combine their work into one manuscript.

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    • This is a great article by two great investigators. Misuse of statistics lead either Twain or Disraeli to denote "lies, damned lies and statistics". Always read the methods section of every paper. Inappropriate censoring in Kaplan-Meier analyses https://t.co/ZxpPISMOHu