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Mashup Score: 12Human Hair Graying Revisited: Principles, Misconceptions, and Key Research Frontiers - 2 month(s) ago
Hair graying holds psychosocial importance and serves as an excellent model for studying human pigmentation and aging in an accessible miniorgan. Curr…
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Mashup Score: 5
Epidermal differentiation is ultimately aimed at the formation of a functional barrier capable of protecting the organism from the environment while p…
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Mashup Score: 13
Early detection of melanoma is critical to good patient outcomes, but we still know little about the mechanisms of early melanoma development. Normal …
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Mashup Score: 5How Efforts to Understand Somatic Mosaicism Will Impact Dermatology - 2 month(s) ago
Author links open overlay panel Ryland D. Mortlock 1 2 3, Keith A. Choate 1 2 4 The skin harbors unique SNV signatures compared with other tissues. A higher proportion of somatic SNVs in skin are related to UV light exposure, and skin has a higher overall SNV burden than any other tissue. Damaging SNVs in genes related to skin cancer can be found in normal sun-exposed skin (Martincorena et al, 2015), and their proportion increases with age. In addition, the number of somatic SNVs and the specific signature
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Mashup Score: 4Deciphering the Pathobiological Impairment Mechanisms of the Lymphatic System during Secondary Lymphedema Progression - 2 month(s) ago
Secondary lymphedema resulting from oncologic treatment presents one of the most frequent, however underestimated complications of oncologic surgery. It is nowadays a common understanding that the lymphatic insult presents the trigger of a number of reactions, leading eventually to lymphedema onset and progression. Importantly, though, the triggering lymphatic insult does not present the sole cause of lymphedema, as such would correspondingly imply a “stop-cork” mechanism upon the lymphatic Despite
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Mashup Score: 4MAPK-Activating Gene Fusions in Congenital Nevi - 2 month(s) ago
Author links open overlay panel Jessica L. Flesher 1, David E. Fisher 1 In individual case studies and small cohorts of patients with CMN, fusion genes have been detected that may drive the formation of the lesion (Martins da Silva et al., 2019; Mir et al., 2019). Starting with a larger cohort, Barberan Martin et al. (2023) have identified 11 unique gene fusion combination pairs present in patients with CMN without BRAF or NRAS variants, 10 of which had not yet been described in CMN. Although there is a
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Mashup Score: 9Disentangling Hype from Reality for Artificial Intelligence–Based Skin Cancer Diagnosis: Comment on a Narrative Review - 2 month(s) ago
Author links open overlay panel Crystal T. Chang 1 2, Roxana Daneshjou 1 3 RD has served as an advisor to MDAlgorithms and Revea and received consulting fees from Pfizer, L’Oreal, Frazier Healthcare Partners, and DWA and research funding from UCB. The remaining author states no conflict of interest. There are more references available in the full text version of this
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Mashup Score: 8Empowering the Next Generation of Artificial Intelligence in Dermatology: The Datasets and Benchmarks Track of the Journal of Investigative Dermatology - 2 month(s) ago
Author links open overlay panel Roxana Daneshjou, Harald Kittler RD has served as an advisor to MDAlgorithms and Revea and received consulting fees from Pfizer, L’Oreal, Frazier Healthcare Partners, and DWA and research funding from UCB. HK reports equipment from Derma Medical Systems, Fotofinder, Casio, and Heine; speaker fees from Fotofinder, Eli Lilly, Novartis, Pelpharma, and Roche Posay; medical consultant of Fotofinder, Heine, VI-Institute, and AI Medical Technology; and license fees from Casio,
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Take a look at the Editorial by @RoxanaDaneshjou and @HaraldKittler Empowering the Next Generation of #ArtificialIntelligence in #Dermatology: The Datasets and Benchmarks Track of the Journal of Investigative Dermatology https://t.co/F0b7aCZsHh #dermtwitter #dermresearch… https://t.co/doWBz0yzGK https://t.co/vR8uERJP6R
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Mashup Score: 6
Oxidative stress can result in impaired wound healing in the skin. Topical application of formulated compounds with antioxidant properties can enhance wound healing, but the biocompatibility and delivery of these compounds remain challenging. Melanin is a natural antioxidant and proficient radical scavenger in the skin. Biyashev et al (2023) synthesized nanoscale synthetic melanin particles (SMPs) and examined the effects of topical treatment with these molecules in murine models of chemical- The chronic
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Mashup Score: 10The Syk inhibitor entospletinib abolishes dermal-epidermal separation in a fully human ex vivo model of bullous pemphigoid - 3 month(s) ago
Bullous pemphigoid (BP) is an autoantibody-mediated blistering skin disease characterized by local inflammation and dermal-epidermal separation, with …
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"Human hair greying revisited: Principles, misconceptions, and key research frontiers," a review by Ralf Paus, Alex Sevilla, & James Grichnik https://t.co/ZxjW559Wh7 #JIDJournal #dermscience #dermtwitter https://t.co/h5ZGUjZAQ4