-
Mashup Score: 0Vacancy: co-Editor-in-Chief - 3 month(s) ago
Applications are invited for a co-Editor-in-Chief for Journal of Endocrinology and Journal of Molecular Endocrinology The Society for Endocrinology invites applications for the role of co-Editor-in-Chief for a five-year term starting in January 2025. Journal of Endocrinology and Journal of Molecular Endocrinology are leading basic science journals owned by the Society for Endocrinology, and…
Source: jme.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
-
Mashup Score: 4Prenatal cortisol exposure impairs adrenal function but not glucose metabolism in adult sheep - 3 month(s) ago
Adverse environmental conditions before birth are known to programme adult metabolic and endocrine phenotypes in several species. However, whether increments in fetal cortisol concentrations of the magnitude commonly seen in these conditions can cause developmental programming remains unknown. Thus, this study investigated the outcome of physiological increases in fetal cortisol concentrations on glucose–insulin dynamics and pituitary–adrenal function in adult sheep. Compared with saline treatment, intravenous fetal cortisol infusion for 5 days in late gestation did not affect birthweight but increased lamb body weight at 1–2 weeks after birth. Adult glucose dynamics, insulin sensitivity and insulin secretion were unaffected by prenatal cortisol overexposure, assessed by glucose tolerance tests, hyperinsulinaemic–euglycaemic clamps and acute insulin administration. In contrast, prenatal cortisol infusion induced adrenal hypo-responsiveness in adulthood with significantly reduced cortis
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
-
Mashup Score: 5Top-cited articles of 2023 - 3 month(s) ago
To showcase the outstanding articles published in Journal of Endocrinology, we have collated the top-cited articles of 2023. Explore the collection to make sure you haven’t missed the most popular and exciting articles! Top-cited reviews The links between sleep duration, obesity and type 2 diabetes mellitus Christina Antza et al. Gut microbiome, endocrine control of gut barrier function…
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
-
Mashup Score: 5Vacancy: co-Editor-in-Chief - 4 month(s) ago
Applications are invited for a co-Editor-in-Chief for Journal of Endocrinology and Journal of Molecular Endocrinology The Society for Endocrinology invites applications for the role of co-Editor-in-Chief for a five-year term starting in January 2025. Journal of Endocrinology and Journal of Molecular Endocrinology are leading basic science journals owned by the Society for Endocrinology, and…
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
-
Mashup Score: 2Kisspeptin upregulates β-cell serotonin production during pregnancy - 4 month(s) ago
During pregnancy the maternal pancreatic islets of Langerhans undergo adaptive changes to compensate for gestational insulin resistance. The lactogenic hormones are well established to play a key role in regulating the islet adaptation to pregnancy, and one of the mechanisms through which they act is through upregulating β-cell serotonin production. During pregnancy islet serotonin levels are significantly elevated, where it is released from the β-cells to drive the adaptive response through paracrine and autocrine effects. We have previously shown that placental kisspeptin (KP) also plays a role in promoting the elevated insulin secretion and β-cell proliferation observed during pregnancy, although the precise mechanisms involved are unclear. In the present study we investigated the effects of KP on expression of pro-proliferative genes and serotonin biosynthesis within rodent islets. Whilst KP had limited effect on pro-proliferative gene expression at the time points tested, KP did s
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
-
Mashup Score: 4Neuronal insulin signaling and resistance: a balancing act of kinases and phosphatases - 5 month(s) ago
Insulin signaling cascade in peripheral insulin-sensitive tissues regulates whole-body glucose metabolism. Any deregulation in this pathway leads to insulin resistance, ultimately leading to metabolic diseases like type 1 diabetes, type 2 diabetes, and obesity. Insulin signaling in the brain has also been studied for many decades and associated with many primary functions like maintenance of synaptic plasticity, regulation of cognition, and circadian rhythm. Importantly, neuronal insulin signaling has also been associated with the regulation of neuronal glucose uptake. Any impairment in neuronal insulin signaling affecting neuronal glucose uptake has been associated with neurodegenerative disorders like Alzheimer’s disease, the process now being termed as type 3 diabetes. Since the criticality lies in proper signaling cascade, determining important points of deregulation is important. In this review, we have discussed some critical points of such deregulation, dividing them into two cl
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
-
Mashup Score: 4Diffuse traumatic brain injury substantially alters plasma growth hormone in the juvenile rat - 5 month(s) ago
Traumatic brain injury (TBI) can damage the hypothalamus and cause improper activation of the growth hormone (GH) axis, leading to growth hormone deficiency (GHD). GHD is one of the most prevalent endocrinopathies following TBI in adults; however, the extent to which GHD affects juveniles remains understudied. We used postnatal day 17 rats (n = 83), which model the late infantile/toddler period, and assessed body weights, GH levels, and number of hypothalamic somatostatin neurons at acute (1, 7 days post injury (DPI)) and chronic (18, 25, 43 DPI) time points. We hypothesized that diffuse TBI would alter circulating GH levels because of damage to the hypothalamus, specifically somatostatin neurons. Data were analyzed with generalized linear and mixed effects models with fixed effects interactions between the injury and time. Despite similar growth rates over time with age, TBI rats weighed less than shams at 18 DPI (postnatal day 35; P = 0.03, standardized effect size [d] = 1.24), which
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
-
Mashup Score: 6Gestational exposure to cannabidiol leads to glucose intolerance in 3-month-old male offspring - 5 month(s) ago
Reports in North America suggest that up to 20% of young women (18–24 years) use cannabis during pregnancy. This is concerning given clinical studies indicate that maternal cannabis use is associated with fetal growth restriction and dysglycemia in the offspring. Preclinical studies demonstrated that prenatal exposure to Δ9-tetrahydrocannabinol, the main psychoactive component of cannabis, in rat dams led to female-specific deficits in β-cell mass and glucose intolerance/insulin resistance. Yet to date, the contributions of cannabidiol (CBD), the primary nonpsychoactive compound in cannabis, remain elusive. This study aimed to define the effects of in utero cannabidiol (CBD) exposure on postnatal glucose regulation. Pregnant Wistar rat dams received daily intraperitoneal injections of either a vehicle solution or 3 mg/kg of CBD from gestational day (GD) 6 to parturition. CBD exposure did not lead to observable changes in maternal or neonatal outcomes; however, by 3 months of age male C
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
-
Mashup Score: 3Endocrine Society of Australia Special Collection - 6 month(s) ago
In collaboration with the Endocrine Society of Australia, and led by Guest Editors Professor Bu Yeap and Professor Tim Cole, Journal of Endocrinology (JOE) has invited this collection of articles from some of the region’s leading Endocrine researchers. Collection Guest Editors: Professor Timothy Cole, Guest Editor Professor of Biochemistry & Molecular…
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
-
Mashup Score: 6RISING STARS: Mechanistic insights into maternal–fetal cross talk and islet beta-cell development - 6 month(s) ago
The metabolic health trajectory of an individual is shaped as early as prepregnancy, during pregnancy, and lactation period. Both maternal nutrition and metabolic health status are critical factors in the programming of offspring toward an increased propensity to developing type 2 diabetes in adulthood. Pancreatic beta-cells, part of the endocrine islets, which are nutrient-sensitive tissues…
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
📢 Applications for Co-Editor-in-Chief of Journal of Endocrinology and Journal of Molecular Endocrinology are open! Lead these @Soc_Endo prestigious publications for a 5-year term starting January 2025. Don't miss this opportunity! Learn more 👉 https://t.co/na5Ml7coC1 https://t.co/NuxpZ8LXT9