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Mashup Score: 6Global burden of cutaneous melanoma incidence attributable to ultraviolet radiation in 2022 - 1 month(s) ago
Cutaneous melanoma (CM) is on the rise, not only because of population growth and aging, but because of changing recreational habits and increased sun exposure. However, the relationship between UV r…
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet
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Mashup Score: 2Prognostic and predictive implications of sterile alpha motif and HD domain‐containing protein 1 (SAMHD1) expression in breast cancer - 1 month(s) ago
What’s new? Sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTP hydrolase, acts as tumor suppressor in cancer, but its role in breast cancer is not well-studied. Here, the authors…
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet-
NOW ONLINE! New research shows that SAMHD1, a dNTP hydrolase, is linked to better outcomes and could serve as a promising #Biomarker in early breast cancer, especially in basal-like and HER2-enriched subtypes. 🔓 OPEN ACCESS ➡️https://t.co/8094sj3CgR https://t.co/0y8pAKl1dM
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Mashup Score: 6Efficacy and safety of JMT103 in patients with bone metastases from solid tumors: A randomized Phase Ib clinical trial - 1 month(s) ago
What’s new? Bone metastases are common in a variety of cancer types, causing increased pain and worse outcomes. Suppression of bone turnover, such as with the monoclonal antibody denosumab, results i…
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet-
Today is #ClinicalTrialsDay! JMT103, a RANKL-targeting antibody, safely and effectively reduces bone turnover in cancer patients with bone metastases, offering a promising option to ease complications. #PoweredbyPurpose #CTD2025 🔓 ➡️ https://t.co/OvDnmK2gdi @uicc @ACRPDC https://t.co/mWRESe6DCo
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Mashup Score: 0Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture - 2 month(s) ago
Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enh…
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet-
New review by @IsabelleSeufert et al. shows how changes in genome structure & protein assembly drives cancer by disrupting enhancer-promoter communication and targeting it in #CancerTherapy. Also presented at the IJC Symposium by @KarstenRippe 🔓➡️ https://t.co/9QmKnmQ8vX @uicc https://t.co/7qrXm8vIzV
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Mashup Score: 0
What’s new? Neurological immune-related adverse events from immune checkpoint inhibitor therapy are rare, but potentially life-threatening. Here, the authors identified serum neurofilament light chai…
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet-
NOW ONLINE! New research identifies NFL and GFAP as promising biomarkers for neurological immune-related adverse events from immune checkpoint therapy. #Immunotherapy 🔓OPEN ACCESS ➡️https://t.co/gFrcaeiXEe https://t.co/hkRFYaokLE
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Mashup Score: 1Polyamine depletion limits progression of acute leukaemia - 2 month(s) ago
Cancer cells are highly reliant on polyamines for their rapid growth and cellular function. However, the few clinical studies that tested the efficacy of polyamine biosynthesis inhibition drugs inclu…
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet-
NOW ONLINE! Blocking both the synthesis and uptake of polyamines kills leukemia cells and delays disease progression, thus, offering a new treatment approach against #AcuteLeukemia 🔒 FULL ACCESS ➡️ https://t.co/J2UpUB1ObF https://t.co/1wwiPfl1md
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Mashup Score: 6
Alterations in chromatin conformation and post-translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistanc…
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet-
NOW ONLINE! New review by @florian_perner et al. focuses on how targeted epigenetic drugs, like the emerging SWI/SNF‑focused compounds, are reshaping #CancerTherapy. Also presented at the IJC Symposium on 14-Jan by Prof. Michael Lübbert 🔓➡️ https://t.co/RGbWdFnYBm @uicc https://t.co/0o1DXED9pU
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Mashup Score: 0Personalized dendritic cell vaccine in multimodal individualized combination therapy improves survival in high‐risk pediatric cancer patients - 2 month(s) ago
While dendritic cell-based vaccines have emerged as one of the promising and well-tolerated immunotherapy options for cancers, most studies have been conducted in adults. Using the N-of-1 approach in…
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet-
#WorldImmunizationWeek Personalized dendritic cell vaccines show promise as a powerful, well-tolerated immunotherapy for high-risk pediatric solid tumours, especially when combined with immune checkpoint inhibitors. 🔓OPEN ACCESS ➡️ https://t.co/x0eN1UCXl4 @uicc https://t.co/rT2qVm6Y2e
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Mashup Score: 0Synchronous bilateral Wilms tumors are prone to develop independently and respond differently to preoperative chemotherapy - 2 month(s) ago
What’s new? Wilms tumor (WT), which accounts for about 90% of childhood kidney cancers, occurs bilaterally in fewer than 10% of cases. However, bilateral WT is generally more aggressive than unilater…
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet-
NOW ONLINE! New research shows that the left and right tumors in bilateral Wilms tumor—an aggressive form of childhood #KidneyCancer — can be genetically distinct and respond differently to chemotherapy. 🔒FULL ACCESS ➡️ https://t.co/m4hdVXkxpw https://t.co/rgqZv4SX8q
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Mashup Score: 0Cohesin mutations and chromatin changes in cancer - 2 month(s) ago
The identification of recurrent mutations in genes encoding the cohesin complex in cancer was among the most unexpected findings from cancer exome sequencing studies. Cohesin is a multi-subunit prote…
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet-
NOW ONLINE! This review focuses on the prevalence of cohesion mutations, and their influence on chromatin organization and gene regulation across different #Cancer types. Also presented as a talk at the IJC Symposium on 14Jan by Zuzana Tothova 🔒➡️https://t.co/CAi3t0uLsO @uicc https://t.co/ubQ5dQWyLd
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NOW ONLINE! New Study from @IARCWHO estimates global burden of cutaneous #melanoma (CM) caused by excess #UV https://t.co/qkbzFGT8rz https://t.co/bCc1efJnt6