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Mashup Score: 9Acute hypoxia does not alter tumor sensitivity to FLASH radiotherapy - 3 month(s) ago
Tumor hypoxia is a major cause of treatment resistance, especially to radiotherapy at conventional dose rate (CONV), and we wanted to assess whether h…
Source: www.sciencedirect.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1
The quiet withdrawal of a 2021 cancer study by Dr. Sam Yoon highlights scientific publishers’ lack of transparency around data problems.
Source: www.nytimes.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 17Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization - 3 month(s) ago
Enhanced endogenous DNA damage, aberrant ATM activity, and elevated HR render p53-mutant GBM cells susceptible to AZD1390-mediated radiosensitization.
Source: www.science.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 5Home | Spranger Lab - 3 month(s) ago
The goal of the Spranger lab is to understand how a range of tumor cell-intrinsic, tissue-specific and environmental factors directly impact the interaction between the cancer and the immune system. NextPrevious Dendritic cells within the tumor-immune microenvironment. We are interested understanding the contribution of dendritic cells and other antigen presenting cells to the local…
Source: spranger-lab.mit.eduCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 11Targeting PARP for Chemoradiosensitization: Opportunities, Challenges, and the Road Ahead - 3 month(s) ago
As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright
Source: www.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
⚠️This has aged well⚠️ ➡️https://t.co/K5ubeCKAtM As I may have learned from Herman Suit: Friendly persistence pays off‼️😊 Looking forward to developing PARPi in #lungcancer 💊☢️🙏 @MGHThoracicOnc @StevenLin_MDPhD @SalmaJabbour1 @JustinGainor @finn_corinne @KrauseProf… https://t.co/DVNMnPYmed https://t.co/xdOCKDXYMr
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Mashup Score: 20Differential Formation of Stress Granules in Radiosensitive and Radioresistant Head and Neck Squamous Cell Carcinoma Cells - 4 month(s) ago
Stress granules (SGs) are cytoplasmic aggregates in which mRNAs and specific proteins are trapped in response to a variety of damaging agents. They participate in the cellular defense mechanisms. Currently, their mechanism of formation in response to ionizing radiation and their role in tumor-cell radiosensitivity remain elusive.
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 45Five-Day Spacing of Two Fractionated Ablative Radiotherapies Enhances Antitumor Immunity - 4 month(s) ago
This study aimed to enhance tumor control and abscopal effects by applying diverse stereotactic ablative radiation therapy (SABR) schedules.
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 20Stereotactic Body Radiotherapy in Locally Advanced Non–Small Cell Lung Cancer—Is This the Future? - 4 month(s) ago
Stereotactic body radiotherapy (SBRT), also known as stereotactic ablative radiotherapy (SABR), is associated with improved local control and overall survival compared with conventionally fractionated, nonablative regimens in early-stage non–small cell lung cancer (NSCLC).1 With modern imaging and…
Source: jamanetwork.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 33Concurrent olaparib and radiotherapy in elderly patients with newly diagnosed glioblastoma: the phase I dose escalation PARADIGM trial - 4 month(s) ago
: Patients with glioblastoma who are elderly or have poor performance status (PS) experience particularly poor clinical outcomes. At the time of study initiation, these patients were treated with short-course radiotherapy (40 Gy in 15 fractions). Olaparib is an oral inhibitor of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) that is well tolerated as a single agent but exacerbates acute radiation toxicity in extracranial sites. Preclinical data predicted that PARP inhibitors would enhance radiosensitivity in glioblastoma without exacerbating adverse effects on the normal brain.
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 15Nerves of the Thorax: Atlas of Normal and Pathologic Findings - 4 month(s) ago
An anatomic and imaging atlas was created to provide detailed information about the six pairs of thoracic nerves (phrenic nerves, vagus nerves, recurrent laryngeal nerves, sympathetic trunks, costal nerves, long thoracic nerves). Serial axial computed tomographic (CT) scans of the normal thorax were obtained and included in the atlas, along with drawings showing the proper location of each nerve relative to adjacent anatomic structures. CT scans obtained in both symptomatic and asymptomatic patients with various thoracic diseases were paired with appropriate drawings and normal CT scans in the atlas. This format was designed to help determine the presence and severity of related disease, including injury from surgery, trauma, or penetrating injury, metastatic disease involvement, and, rarely, primary tumor. Although the nerves of the thorax are rarely identified at cross-sectional imaging, their location can be inferred by localizing easily identified anatomic landmarks. Familiarity wi
Source: pubs.rsna.orgCategories: General Medicine News, Hem/OncsTweet-
@PercyLeeMD @LuisAlberto3P @BLoo_LT_SABR @max_diehn @MFGensheimer @OncoAlert @SBRT_CR @theabzlab This is a good paper depicting course of the nerves in the chest which we have found helpful to consult once in a while! Nerves of the Thorax: Atlas of Normal and Pathologic Findings | RadioGraphics https://t.co/dEh1rddiFs
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RT @VozeninC: Acute hypoxia does not alter tumor sensitivity to FLASH radiotherapy https://t.co/KIjxKwO1Xe