The polymorphism Val158Met in the COMT gene: disrupted… : PAIN
results on its role in fibromyalgia (FM). Here, the SNP Val158Met was analyzed in 294 FM patients (without comorbidities) and 209 healthy controls (without chronic pain). The concurrent impact of Val158Met genotypes and FM comorbid disorders (depression and sleep impairment) on FM risk were tested. In addition, the genotypic distribution of FM patients in relation to pain intensity was evaluated. The G allele (Val) resulted in being more represented in the FM group (57.8%) compared with the control group (48.8%; P = 0.037). Logistic regression highlighted that having the G/G (Val/Val) homozygous genotype was associated with 2 times higher risk of having FM compared with the A/A (Met/Met) carriers (P = 0.038), whereas depression and sleep impairment increased FM risk by 12 and 8 times, respectively (P < 0.001). However, considering only the FM patient group, the A/A homozygous genotype was significantly associated with severe pain intensity (P = 0.007). This study highlighted associatio
