Nature – Whole-genome sequencing of matched serial tumours from patients identifies two key mutagenic factors (APOBEC3 and chemotherapy) and extrachromosomal DNA-forming structural variants that…
Necessity is the mother of invention, but serendipity is often the driving force behind scientific innovation. In this issue of Blood, Sun et al leverage a
Although tyrosine kinase inhibitors (TKIs) are effective against non-small cell lung cancer (NSCLC) harboring sensitizing epidermal growth factor receptor (EGFR) gene mutations, acquired resistance is…
Nature – Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two…
It wasn’t always lonely out here. I have been the only permanent doctor in my little country clinic north of Kingston for eight years now,…
The importance of surrogate endpoints, magnitude of clinical benefit of cancer drugs, and their prices have often been debated in the oncology world. No study,…
The authors show that gut microbiota imbalances provoke systemic inflammation, leading to immunosuppression in tumors at distant sites, such as the lungs. This accelerates lung…
Associations of Internal Medicine Residency Ratings and Certification Examination Scores With Patient Outcomes
Nature Reviews Rheumatology – This Review provides an overview of the pathogenesis, classification and diagnosis of and treatment strategies for adult and paediatric rheumatology patients…
In this issue of Blood, Al-Sawaf and colleagues report on the 6-year results of the CLL14 study, a multicenter open label phase 3 trial for…
The importance of surrogate endpoints, magnitude of clinical benefit of cancer drugs, and their prices have often been debated in the oncology world. No study,…
