The Critical Role of the Variable Domain in Driving Proteotoxicity and Aggregation in Full-length Light Chains – PubMed
Light chain (AL) amyloidosis is the most common systemic amyloid disease characterized by abnormal accumulation of amyloid fibrils derived from immunoglobulin light chains (LCs). Both full-length (FL) LCs and their isolated variable (VL) and constant (CL) domains contribute to amyloid deposits in mu …