The immune system uses two distinct defence strategies against infections: microbe-directed pathogen destruction characterized by type 1 immunity1, and host-directed pathogen containment exemplified by type 2 immunity in induction of tissue repair2. Similar to infectious diseases, cancer progresses with self-propagating cancer cells inflicting host-tissue damage. The immunological mechanisms of…
Nature Communications – The authors investigate the local/regional nature and associated oxidative potential of PM2.5 emission sources in northern India and show that reducing local…
Nature Aging – In vivo human neuroimaging shows that locus coeruleus (LC) integrity changes precede medial temporal tau accumulation, and jointly predict future lower cognition…
Nature Reviews Rheumatology – Beyond the traditional classification of monogenic or complex, many genetic diseases can be considered genetically transitional disease. In this Perspective, the…
Nature Reviews Rheumatology – Rheumatoid arthritis has a substantial genetic component, some of which is associated with the presence of low-frequency or rare variants. Next-generation…
Nature Communications – The temperature-sensitivity of soil dissolved organic carbon (DOC) export is widely debated but limited by the duration of observations. New data from…
Nature Reviews Materials – Disabled scientists are under-represented in STEM and face additional barriers at all career stages. The DisabledInSTEM mentoring programme provides support, an…
Nature Reviews Rheumatology – This Review discusses joint-specific memory (the tendency of arthritis to recur in previously inflamed joints), explores the involvement of resident memory…
Nature Reviews Nephrology – Clinical algorithms that are used to guide medical decision-making often include sex as a variable. However, binary considerations of sex and/or…
Nature Communications – CDK4/6 inhibitors have improved outcomes for patients with ER+ breast cancer, however, those with loss of RB1 function often fail to respond.…
