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    PURPOSE BCL2 is overexpressed and confers prosurvival signaling in malignant lymphoplasmacytic cells in Waldenström macroglobulinemia (WM). Venetoclax is a potent BCL2 antagonist and triggers in vitro apoptosis of WM cells. The activity of venetoclax in WM remains to be clarified. PATIENTS AND METHODS We performed a multicenter, prospective phase II study of venetoclax in patients with previously…

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    • Venetoclax in Previously Treated Waldenström Macroglobulinemia [Nov 18, 2021] Castillo et al. @JCO_ASCO https://t.co/DOON0JS5Dx #NCT02677324 #wmsm