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Mashup Score: 2
Temporal trends and clinical trial characteristics independently associated with under‐enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction published i…
Source: Wiley Online LibraryCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 5
Temporal trends and clinical trial characteristics independently associated with under‐enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction published i…
Source: Wiley Online LibraryCategories: Cardiologists, Latest HeadlinesTweet-
@NMHheartdoc @mmamas1973 @Drroxmehran The factors indep associated w/ #underenrolment of 👩🏻 in #RCTs may be a place to start. Trial reporting needs to include a breakdown of flow by sex, from screening to consent through to completion. Below are some other steps to close the gaps. #Disparities https://t.co/GNcCaNCzlb https://t.co/3dIbUuuZco
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Mashup Score: 0
Temporal trends and clinical trial characteristics independently associated with under‐enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction published i…
Source: Wiley Online LibraryCategories: Cardiologists, Latest HeadlinesTweet-
👆🏽0 RCTs reported sex breakdown of patients screened/consented, can’t assess role of #screening / #consent in #underenrolment. Without balanced enrolment, often have inadeq power to test for sex diffs in treatment & adverse effects. Recommendations👇🏽https://t.co/GNcCaNCzlb https://t.co/lznIXNyROb
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What does #PI #Gender have to do with 👩🏻underenrolment? We adjusted for type of intervention, recruitment location, funder, etc. Could 👩🏻PI’s design protocols that are less burdensome to 👩🏻patients? Could #consent process be more patient friendly? https://t.co/GNcCaNCzlb https://t.co/dySveEbfTC
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Of 317 RCTs #HFrEF RCTs, 👩🏻 represented 25% of 183K participants, w/ no change in trends 2000-2019. Sex-related #EligibilityCriteria, 👨🏻PIs, drug/device/surgery interventions, N Amer/Euro RCTassociated w/ #underenrolment (20% below sex distribution of Dz) https://t.co/GNcCaNCzlb https://t.co/MwiPQl4311
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#RCT #recruitment should approximate sex-distribution of disease so results are generalizable to pop'n we serve (in some conditions, sex distribution of Dz deviates from 50:50). We defined #underenrolment as 20% below HFrEF sex distribution. #Disparities https://t.co/gcf8U5yv1x https://t.co/kIBhSLg32r