-
Mashup Score: 6Tebentafusp Improves Survival in Advanced Uveal Melanoma - 3 year(s) ago
The results of a large clinical trial show that the investigational immunotherapy tebentafusp, a bispecific fusion protein, improves overall survival in patients with metastatic uveal melanoma. There is no standard treatment for the disease and, once it has spread, many patients do not survive for a year.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 15AMBRA1 Protein Found to Be an Important Tumor Suppressor - 3 year(s) ago
Researchers have shown that the loss of a protein called AMBRA1 can cause tumors to form in mice and is linked with worse outcomes in some human tumors. A lack of AMBRA1 may make some tumors resistant to CDK4/6 inhibitor drugs. The new research may lead to strategies for re-sensitizing cancer cells to these drugs.
Source: National Cancer InstituteCategories: Healthcare Professionals, Latest HeadlinesTweet
-
Mashup Score: 2Topotecan–Berzosertib Combination for Small Cell Lung Cancer - 3 year(s) ago
Combining the chemotherapy drug topotecan and the investigational drug berzosertib shrank tumors in some patients with small cell lung cancer (SCLC), the most aggressive form of lung cancer, according to results from an NCI-supported phase 1 clinical trial. Two phase 2 trials of the combination for SCLC are planned.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 7AMBRA1 Protein Found to Be an Important Tumor Suppressor - 3 year(s) ago
Researchers have shown that the loss of a protein called AMBRA1 can cause tumors to form in mice and is linked with worse outcomes in some human tumors. A lack of AMBRA1 may make some tumors resistant to CDK4/6 inhibitor drugs. The new research may lead to strategies for re-sensitizing cancer cells to these drugs.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 5Immunotherapy Improves Survival in Advanced Esophageal Cancer - 3 year(s) ago
In people with advanced esophageal cancer, combining nivolumab (Opdivo) with either chemotherapy or ipilimumab (Yervoy) improved how long they lived, according to results from a large clinical trial. Results from the trial, CheckMate 648, should change current clinical practice, experts said.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 2Immunotherapy Improves Survival in Advanced Esophageal Cancer - 3 year(s) ago
In people with advanced esophageal cancer, combining nivolumab (Opdivo) with either chemotherapy or ipilimumab (Yervoy) improved how long they lived, according to results from a large clinical trial. Results from the trial, CheckMate 648, should change current clinical practice, experts said.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 6Blinatumomab Effective for Children with Relapsed Leukemia - 3 year(s) ago
The immunotherapy drug blinatumomab (Blincyto) is more effective than chemotherapy in treating B-cell acute lymphoblastic leukemia (B-ALL) that has relapsed in children and young adults, results of two randomized clinical trials show.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 5Vemurafenib and Rituximab for Hairy Cell Leukemia - 3 year(s) ago
In a small study, vemurafenib (Zelboraf) and rituximab (Rituxan) helped 85% of participants stay in remission for nearly 3 years. The study involved 30 people with hairy cell leukemia that had come back after or had not responded to previous treatment.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 4Avasopasem May Make Radiation Therapy More Effective - 3 year(s) ago
A drug called avasopasem manganese (AVA), which has been found to protect normal tissues from radiation therapy, can also make cancer cells more vulnerable to radiation treatment, a new study in mice suggests. AVA is already being tested in early clinical trials against several cancers, including pancreatic cancer.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 1Nivolumab and Relatlimab for Advanced Melanoma - 3 year(s) ago
People with advanced melanoma treated with two immunotherapy drugs—nivolumab (Opdivo) and a new drug called relatlimab, which targets a protein called LAG-3—lived longer without their cancer getting worse than those treated only with nivolumab, according to results from a large clinical trial.
Source: National Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
The immunotherapy drug tebentafusp improves survival in advanced uveal melanoma: https://t.co/iOCkbGF1oU #NCICancerCurrentsblog #repost https://t.co/fZGwJMLSOL