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Mashup Score: 2Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer - 1 month(s) ago
PURPOSE This review summarizes the published evidence on the clinical impact of using next-generation sequencing (NGS) tests to guide management of patients with cancer in the United States. METHODS We performed a comprehensive literature review to identify recent English language publications that presented progression-free survival (PFS) and overall survival (OS) of patients with advanced cancer receiving NGS testing. RESULTS Among 6,475 publications identified, 31 evaluated PFS and OS among subgroups of patients who received NGS-informed cancer management. PFS and OS were significantly longer among patients who were matched to targeted treatment in 11 and 16 publications across tumor types, respectively. CONCLUSION Our review indicates that NGS-informed treatment can have an impact on survival across tumor types.
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Coordinating an Oncology Precision Medicine Clinic Within an Integrated Health System: Lessons Learned in Year One - 1 month(s) ago
Precision medicine is a term describing strategies to promote health and prevent and treat disease based on an individual’s genetic, molecular, and lifestyle characteristics. Oncology precision medicine (OPM) is a cancer treatment approach targeting cancer-specific genetic and molecular alterations. Implementation of an OPM clinical program optimally involves the support and collaboration of multiple departments, including administration, medical oncology, pathology, interventional radiology, genetics, research, and informatics. In this review, we briefly introduce the published evidence regarding OPM’s potential effect on patient outcomes and discuss what we have learned over the first year of operating an OPM program within an integrated health care system (Aurora Health Care, Milwaukee, WI) comprised of multiple hospitals and clinics. We also report our experience implementing a specific OPM software platform used to embed molecular panel data into patients’ electronic medical recor
Source: institutionalrepository.aah.orgCategories: General Medicine News, Hem/OncsTweet-
Coordinating an Oncology #PrecisionMedicine Clinic w/in an Integrated Health System: Lessons Learned in Year 1 [1/28/19] @mtmdphd Godden, Wham @antonyruggeri @mullane_michael Wilson @shamsvirani Weissman, Ramczyk, Vanderwall @JimW9200 @Aurora_Cancer @JPCRR https://t.co/bxgjOfLhwk https://t.co/yd53qWlVFb
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Mashup Score: 1Role of Community-Based Genomics Programs - 1 month(s) ago
The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO’s conflict of interest policy, please refer to www.asco.org/rwc or po.ascopubs.org/site/ifc. Speakers’ Bureau: Syapse, Novartis, Precision Medicine Travel, Accommodations,
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 11NCI Precision Oncology | LinkedIn - 1 month(s) ago
NCI Precision Oncology | 186 followers on LinkedIn. NCI Privacy Policy: https://www.cancer.gov/policies/privacy-security
Source: www.linkedin.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 3Lurie Cancer Center OncoSET Symposium - 1 month(s) ago
On Friday, April 26th, the OncoSET Symposium will provide healthcare professionals with state of the art information related to new advances in precision medicine looking beyond mutations in cancer treatment and care. The program will focus on improving the detection of fusions and their therapeutic vulnerabilities, enhancing future incorporation of multiomics assays into management decisions and discussing established and future molecular imaging targets. Participants will learn strategies for translating advances in precision medicine to their clinical practice.
Source: www.cancer.northwestern.eduCategories: General Medicine News, Onc News and JournalsTweet-
Join us April 26 for the Lurie Cancer Center OncoSET Symposium — Precision Oncology: Beyond Mutations. View the agenda and register now to learn about strategies for translating advances in #precisionmedicine into practice. https://t.co/dn8dQ2wPSp @NorthwesternMed @NUFeinbergMed https://t.co/pX2YqtJMBk
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Mashup Score: 14Adaptive Darwinian off-target resistance mechanisms to selective RET inhibition in RET driven cancer - 2 month(s) ago
npj Precision Oncology – Adaptive Darwinian off-target resistance mechanisms to selective RET inhibition in RET driven cancer
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Coordinating an Oncology Precision Medicine Clinic Within an Integrated Health System: Lessons Learned in Year One - 2 month(s) ago
Precision medicine is a term describing strategies to promote health and prevent and treat disease based on an individual’s genetic, molecular, and lifestyle characteristics. Oncology precision medicine (OPM) is a cancer treatment approach targeting cancer-specific genetic and molecular alterations. Implementation of an OPM clinical program optimally involves the support and collaboration of multiple departments, including administration, medical oncology, pathology, interventional radiology, genetics, research, and informatics. In this review, we briefly introduce the published evidence regarding OPM’s potential effect on patient outcomes and discuss what we have learned over the first year of operating an OPM program within an integrated health care system (Aurora Health Care, Milwaukee, WI) comprised of multiple hospitals and clinics. We also report our experience implementing a specific OPM software platform used to embed molecular panel data into patients’ electronic medical recor
Source: institutionalrepository.aah.orgCategories: General Medicine News, Hem/OncsTweet-
Coordinating an Oncology #PrecisionMedicine Clinic w/in an Integrated Health System: Lessons Learned in Year 1 [1/28/19] @mtmdphd Godden, Wham @antonyruggeri @mullane_michael Wilson @shamsvirani Weissman, Ramczyk, Vanderwall @JimW9200 @Aurora_Cancer @JPCRR https://t.co/bxgjOfLhwk https://t.co/yd53qWlVFb
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Mashup Score: 14Adaptive Darwinian off-target resistance mechanisms to selective RET inhibition in RET driven cancer - 2 month(s) ago
npj Precision Oncology – Adaptive Darwinian off-target resistance mechanisms to selective RET inhibition in RET driven cancer
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 31Enhertu granted Priority Review in the US for patients with metastatic HER2-positive solid tumours - 3 month(s) ago
AstraZeneca and Daiichi Sankyo’s supplemental Biologics License Application (sBLA) for Enhertu (trastuzumab deruxtecan) has been accepted and granted Priority Review in the US for the treatment of adult patients with unresectable or metastatic HER2-positive (immunohistochemistry [IHC] 3+) solid tumours who have received prior treatment or who have no satisfactory alternative treatment options. The sBLA is based on data from the ongoing DESTINY-PanTumor02 Phase II trial where Enhertu demonstrated clinically
Source: www.astrazeneca.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 02024 Health IT trends in India: Expanded healthcare AI applications - 3 month(s) ago
Aside from clinical decision and diagnosis support, AI technology is also anticipated to assist with personalised treatments, clinical trials, and self health management, says Augnito founder Rustom
Source: www.healthcareitnews.comCategories: General Medicine News, Future of MedicineTweet
Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer [Jun 7, 2023] Gibbs et al. @JCOPO_ASCO https://t.co/QM9IBjqxzr #PrecisionMedicine https://t.co/DSgDlL2kkU