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Classification of thyroid follicular neoplasms can be challenging for pathologists. Introduction of noninvasive follicular thyroid neoplasms with papillary-like nuclear features, the utilization of immunohistochemistry, and molecular analysis are all thought to be valuable diagnostic adjuncts. Our aim was to determine whether interobserver variability for follicular neoplasms has improved since…
Source: SurgeryCategories: Endocrinology, Latest HeadlinesTweet
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Mashup Score: 1
Lineage plasticity is a source of intratumoural heterogeneity and enables tumour adaptation to an adverse tumour microenvironment, eventually leading to therapeutic resistance. The authors of this Review provide an overview of the impact of lineage plasticity on cancer progression and therapy resistance, with a focus on neuroendocrine transformation in lung and prostate tumours, and discuss…
Source: Nature Reviews Clinical OncologyCategories: Hem/OncsTweet-
As a #pathologist, I find lineage transformation in cancer (in particular adenocarcinoma to neuroendocrine) fascinating. Here's a review from @charlesrudin @triparnasen (Go Triparna!) @CharlesSawyers @dana_peer @sloan_kettering in @NatRevClinOncol https://t.co/snD1uNHGdL https://t.co/R3S7Bg2b7e
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Malignancy is in the eye of the beholder. Not so good inter-observer agreement for thyroid follicular neoplasms among #pathologist. When you add molecular markers to the mix- things get worse! #thyroid @EndoJournalClub @thancfoundation #EndoTwitter https://t.co/4g5ARzIXTG