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Mashup Score: 21
Objective We aimed to investigate the association of cardiorespiratory fitness (CRF) with cognitive function and dementia risk, taking genetic predisposition for dementia into account. Methods Within the UK Biobank, 61 214 dementia-free participants aged 39–70 years were followed for up to 12 years. CRF score was estimated using a 6 min submaximal exercise test on a stationary bike and divided into tertiles (ie, low, moderate, and high; standardised by age and sex). Global cognitive function was evaluated at baseline. Dementia was identified based on medical history and medical records. Genetic predisposition for dementia was estimated using the polygenic risk score for Alzheimer’s disease (PRSAD), tertiled as low, moderate, or high. Data were analysed using linear regression, Poisson regression, and Laplace regression. Results Compared with low CRF, high CRF was related to better global cognitive function (β=0.05, 95% CI 0.04 to 0.07). Over the follow-up period, 553 individuals develo
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 18Association of cardiorespiratory fitness with dementia risk across different levels of genetic predisposition: a large community-based longitudinal study - 1 month(s) ago
Objective We aimed to investigate the association of cardiorespiratory fitness (CRF) with cognitive function and dementia risk, taking genetic predisposition for dementia into account. Methods Within the UK Biobank, 61 214 dementia-free participants aged 39–70 years were followed for up to 12 years. CRF score was estimated using a 6 min submaximal exercise test on a stationary bike and divided into tertiles (ie, low, moderate, and high; standardised by age and sex). Global cognitive function was evaluated at baseline. Dementia was identified based on medical history and medical records. Genetic predisposition for dementia was estimated using the polygenic risk score for Alzheimer’s disease (PRSAD), tertiled as low, moderate, or high. Data were analysed using linear regression, Poisson regression, and Laplace regression. Results Compared with low CRF, high CRF was related to better global cognitive function (β=0.05, 95% CI 0.04 to 0.07). Over the follow-up period, 553 individuals develo
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet-
⚠️ How can I lower my risk of dementia? 📉 People with a genetic predisposition for dementia could reduce their risk by up to 35% through increased cardiorespiratory fitness 🤯 HOT OFF THE PRESS 🔥 New #OriginalResearch 📄 #FREE ➡️ https://t.co/6Ap0FsnXsV https://t.co/yIOHJo8Bxj
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Mashup Score: 18Association of cardiorespiratory fitness with dementia risk across different levels of genetic predisposition: a large community-based longitudinal study - 1 month(s) ago
Objective We aimed to investigate the association of cardiorespiratory fitness (CRF) with cognitive function and dementia risk, taking genetic predisposition for dementia into account. Methods Within the UK Biobank, 61 214 dementia-free participants aged 39–70 years were followed for up to 12 years. CRF score was estimated using a 6 min submaximal exercise test on a stationary bike and divided into tertiles (ie, low, moderate, and high; standardised by age and sex). Global cognitive function was evaluated at baseline. Dementia was identified based on medical history and medical records. Genetic predisposition for dementia was estimated using the polygenic risk score for Alzheimer’s disease (PRSAD), tertiled as low, moderate, or high. Data were analysed using linear regression, Poisson regression, and Laplace regression. Results Compared with low CRF, high CRF was related to better global cognitive function (β=0.05, 95% CI 0.04 to 0.07). Over the follow-up period, 553 individuals develo
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet-
⚠️ How can I lower my risk of dementia? 📉 People with a genetic predisposition for dementia could reduce their risk by up to 35% through increased cardiorespiratory fitness 🤯 HOT OFF THE PRESS 🔥 New #OriginalResearch 📄 #FREE ➡️ https://t.co/6Ap0FsnXsV https://t.co/yIOHJo8Bxj
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Mashup Score: 16
Objective To examine the long-term association of objectively measured moderate-to-vigorous physical activity (MVPA) and its longitudinal changes with progression to chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) and overweight/obesity. Methods This study included 1746 participants in the Look AHEAD trial with baseline estimated glomerular filtration rate (eGFR)≥60 mL/min/1.73 m2. MVPA was measured at baseline, year 1, year 4 and year 8 using an RT3 accelerometer. The outcome was progression to CKD, defined as eGFR<60 mL/min per 1.73 m2 with a drop of ≥30% or end-stage kidney disease. Cox hazards models were fitted to examine the association between MVPA and outcomes. Results Over a median follow-up of 12.0 years, 567 participants experienced progression to CKD. Overall, there was a linear inverse association of cumulative average total MVPA (per 100 min/week higher amount, HR: 0.91; 95% CI: 0.86 to 0.96) and MVPA accumulated in bouts of ≥10 min (per 100 minutes/we
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet-
📣 "Being physically active is one of the cornerstones to preventing renal disease in type 2 diabetes" ✋ 🏃♀️ NEW #OriginalResearch looks at the association of accelerometer-measured PA and its change with progression to CKD in adults with T2DM📄 #FREE 👉 https://t.co/vcheuC72Kd https://t.co/s5ZaPFLw1q
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Mashup Score: 16
Objective To examine the long-term association of objectively measured moderate-to-vigorous physical activity (MVPA) and its longitudinal changes with progression to chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) and overweight/obesity. Methods This study included 1746 participants in the Look AHEAD trial with baseline estimated glomerular filtration rate (eGFR)≥60 mL/min/1.73 m2. MVPA was measured at baseline, year 1, year 4 and year 8 using an RT3 accelerometer. The outcome was progression to CKD, defined as eGFR<60 mL/min per 1.73 m2 with a drop of ≥30% or end-stage kidney disease. Cox hazards models were fitted to examine the association between MVPA and outcomes. Results Over a median follow-up of 12.0 years, 567 participants experienced progression to CKD. Overall, there was a linear inverse association of cumulative average total MVPA (per 100 min/week higher amount, HR: 0.91; 95% CI: 0.86 to 0.96) and MVPA accumulated in bouts of ≥10 min (per 100 minutes/we
Source: bjsm.bmj.comCategories: General Medicine News, RheumatologyTweet-
📣 "Being physically active is one of the cornerstones to preventing renal disease in type 2 diabetes" ✋ 🏃♀️ NEW #OriginalResearch looks at the association of accelerometer-measured PA and its change with progression to CKD in adults with T2DM📄 #FREE 👉 https://t.co/vcheuC72Kd https://t.co/s5ZaPFLw1q
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⚠️ How can I lower my risk of dementia? 📉 People with a genetic predisposition for dementia could reduce their risk by up to 35% through increased cardiorespiratory fitness 🤯 HOT OFF THE PRESS 🔥 New #OriginalResearch 📄 #FREE ➡️ https://t.co/6Ap0FsnXsV https://t.co/yIOHJo8Bxj