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Mashup Score: 3The Ongoing Debate: Progression-Free vs Overall Survival as the Primary Study Outcome in Therapeutic Cancer Trials - 10 day(s) ago
Is it time to end the rhetoric that denies the benefit of antineoplastic pharmaceutical agents due to the absence of an OS improvement in a clinical trial?
Source: www.onclive.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 0MT-302 Utilizes Novel Mechanism of Action to Offer a Unique Treatment in Epithelial Tumors - 10 day(s) ago
Rasha Cosman, BSc, MBBS, FRACP, and Charlotte Lemech, MBBS, discuss the phase 1 MYE Symphony study (NCT05969041) of MT-302 in advanced or metastatic epithelial cancers.
Source: www.onclive.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 23
KEYTRUDA ® (pembrolizumab) plus chemotherapy followed by maintenance with LYNPARZA ® (olaparib), with or without bevacizumab, demonstrated a statistically significant and clinically meaningful improvement in PFS compared to chemotherapy alone The study did not reach its secondary endpoint of overall survival Merck (NYSE: MRK), known as MSD outside of the United States and Canada, today announced that the Phase 3 KEYLYNK-001 trial evaluating KEYTRUDA ® (pembrolizumab) plus chemotherapy followed by maintenance with LYNPARZA ® (olaparib), with or without bevacizumab, as a first-line treatment for people with BRCA non-mutated advanced epithelial ovarian cancer met its primary endpoint of progression-free survival (PFS). At the final analysis conducted by an independent Data Monitoring Committee, the KEYTRUDA plus LYNPARZA regimen demonstrated a statistically significant and clinically meaningful improvement in PFS for these patients compared to chemotherapy alone. The study did not reach
Source: www.merck.comCategories: General Medicine News, PayerTweet
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Mashup Score: 5
Leo I. Gordon, MD, parses major changes to the 2024 NCCN guidelines for the treatment of patients with MCL, MZL, and follicular lymphoma.
Source: www.onclive.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 3Novel PI3Kα Inhibitor STX-478 Offers Precise Treatment and Reduced Toxicity for Solid Tumors - 11 day(s) ago
Alberto Montero, MD, MBA, discusses the importance of PI3Kα pathway inhibition in solid tumors and expands on the unique mechanism of action of STX-478.
Source: www.onclive.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 0
Nemvaleukin with and without pembrolizumab yielded promising anti-tumor activity and was well tolerated in patients with advanced solid tumors.
Source: www.cancernetwork.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 2
The FDA approved the PATHWAY HER2 (4B5) test to identify patients with HER2-positive biliary tract cancer who are eligible for treatment with zanidatamab.
Source: www.onclive.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 5Dr Patel on the Utility of the IPS Test in Solid Tumors - 14 day(s) ago
Sandip P. Patel, MD, discusses the Immune Profile Score and how it may be used to inform decisions with immune checkpoint inhibitor therapy in solid tumors.
Source: www.onclive.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 9Assessing 2024 Oncology Advances and Looking Ahead - 15 day(s) ago
Neil M. Iyengar, MD, highlights the biggest advances in oncology, and where he expects the field to move next.
Source: www.cancernetwork.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 3Novel PI3Kα Inhibitor STX-478 Offers Precise Treatment and Reduced Toxicity for Solid Tumors - 15 day(s) ago
Alberto Montero, MD, MBA, discusses the importance of PI3Kα pathway inhibition in solid tumors and expands on the unique mechanism of action of STX-478.
Source: www.onclive.comCategories: General Medicine News, Oncologists1Tweet
The Ongoing Debate: Progression-Free vs Overall Survival as the Primary Study Outcome in Therapeutic Cancer Trials @DrMaurieMarkman @cityofhope #oncology https://t.co/h7YpSDW9Us