MicroabstractMultiple myeloma involving the central nervous system (CNS-MM) has a poor prognosis. This retrospective study evaluated outcomes of 45 patients treated with CNS-directed radiation therapy. Six of these patients had survival ranging from 11.2 to 52.2 months from CNS-MM diagnosis. Thus, aggressive multimodality therapy shows promise in achieving durable CNS control and longer-term survival in a small subset of patients.