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    Mitomycin C (MMC) is often used as an intravesical therapy for low / intermediate risk non-muscle invasive bladder cancer. This randomised controlled trial (RCT) was designed to assess the safety and efficacy of MMC + cytosine arabinoside (Ara-C). Ara-C was an alkalinising agent with the rationale being evidence of increased tumour exposure of MMC in alkaline pH. Randomisation was performed prior…

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    • #JournalReviews - A new clinical trial compares the effectiveness of Intravesical mitomycin C (#MMC) alone vs MMC + cytosine arabinoside in treating non-muscle-invasive bladder cancer 🔬💊💪 #BladderCancer https://t.co/oisycNvNLl #ClinicalTrial #CancerResearch

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    /Purpose: Intra-Tenon or subconjunctival injection of a solution of Mitomycin C (MMC) and 1% preservative-free lidocaine (as an anesthetic) has gained popularity for its use in trabeculectomy, a filtering surgery for glaucoma. To our knowledge, no studies have analyzed the impact of lidocaine on the cytotoxic effects of MMC in this setting. This study was conducted to evaluate in vitro fibroblast…

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    • In vitro study found an increase in cytotoxicity when #MMC was combined with 1% PF lidocaine. Lidocaine did not inhibit MMC cytotoxicity & exhibited a significant cytotoxic effect on its own. #ophthalmology #glaucoma https://t.co/wmQFdSrJZj https://t.co/o2rkRcliEd