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Mashup Score: 0Neuroanatomic Signatures in Brachioradial Pruritus, Chronic Prurigo, and Atopic Dermatitis - 7 month(s) ago
In September 2022, Agelopoulos et al. (2023) published an investigation on the density and distribution of intraepithelial sensory nerve fibers using pan-neuronal marker, protein gene product 9.5, in skin biopsies from patients with chronic nodular prurigo (CNPG), atopic dermatitis (AD), and brachioradial pruritus (BRP) and from healthy controls. In addition to a reduced number of intraepidermal nerve fibers in biopsies from all patients compared with those from healthy controls, different neuronal branching patterns were recognized in CNPG, BGP, and AD (Agelopoulos et al., 2023).
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 1Real-World Implementation and Outcomes of Adalimumab Therapeutic Drug Monitoring in Psoriasis: A National Specialized Center Experience - 8 month(s) ago
Serum adalimumab concentration is a biomarker of treatment response but therapeutic drug monitoring (TDM) is yet to be implemented in routine psoriasis care. We incorporated adalimumab TDM in a national specialized psoriasis service and evaluated it using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) implementation science framework. We undertook pre-implementation planning (validating local assays) and implementation interventions targeted to patients (pragmatic sampling at routine reviews), clinicians (introduction of a TDM protocol), and healthcare systems (adalimumab TDM as a key performance indicator).
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 1The Human Skin Cell Atlas: Mapping the Organ at Unprecedented Depth - 8 month(s) ago
In their recent paper, Almet et al. (2023) provide a framework for the research community aiming to standardize single-cell datasets and find common terminology to more accurately describe cutaneous cell populations and functional cell states. More specifically, the authors propose to construct a Human Skin Cell Atlas mainly derived from single-cell RNA-sequencing studies as part of a worldwide consortium organized by and integrated into the Human Cell Atlas Initiative. As challenging as it may sound, such an undertaking is necessary and worthwhile because it will help to deconvolute complex datasets for the benefit of clarity and reproducibility in cutaneous research.
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 5Autophagy Controls the Protein Composition of Hair Shafts - 8 month(s) ago
Hair shafts are formed by a special mode of keratinocyte (KC) differentiation (Harland and Plowman, 2018), which is characterized by the accumulation of hair keratins (keratin [K]31–K40, K81–K90) and keratin-associated proteins, cell death by cornification, and integration of the dead cells into the growing hair shaft (Jones et al., 2018) (Figure 1a). The death of hair KCs is associated with the breakdown of the nucleus and other organelles (Fischer et al., 2011; Jones et al., 2018). Autophagy is a major intracellular degradation process that is controlled by autophagy-related genes (Mizushima and Komatsu, 2011).
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 2
As artificial intelligence (AI) continually advances, its potential role in clinical decision making has been increasingly explored. Growing attention has surrounded stress testing the readiness of AI models for clinical utility by quantifying the performance of large language models (LLMs), such as ChatGPT (OpenAI, San Francisco, CA) and its successor GPT-4 (OpenAI), on standardized medical examinations. However, LLMs have predictable limitations, such as older models struggling with higher-order questions (Ali et al., 2023, 2021).
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 0
Innate lymphoid cells (ILCs) are essential players in the skin-associated immune system, nevertheless little is known about their proteomes and proteomic diversity. Here, we describe over 6,600 proteins constitutively expressed by ILC2s and ILC3s from healthy human skin and blood using state-of-the-art proteomics. Although the vast majority of proteins was expressed by both ILC subsets and in both compartments, the skin ILC2s and ILC3s were more distinct than their counterparts in blood. Only skin ILC3s expressed uniquely detected proteins.
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 2
A hair whorl is a patch of hair growing in a circular pattern around a point specified by hair follicle (HF) orientations (Ziering and Krenitsky, 2003). As an easily observed human trait, established between 10 and 16 weeks of gestation (Smith and Gong, 1973), scalp hair whorl pattern is typically defined by the whorl number (single or double whorl) and whorl direction (e.g., clockwise, counterclockwise, or diffuse) (Ziering and Krenitsky, 2003). Because atypical whorl patterns have been observed in patients with abnormal neurological development (Smith and Gong, 1973), understanding the genetic basis of whorl patterns may help to unravel important biological processes.
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 1IL-17-mediated downregulation of miR-101 facilitates expression of EZH2 to promote epidermal hyperplasia in psoriasis. - 9 month(s) ago
Psoriasis is a chronic, systemic autoimmune disease (Rendon and Schakel, 2019). Psoriatic skin lesions are characterized by excessive keratinocyte proliferation and poor differentiation. This hyperproliferative phenotype is fostered by epigenetic factors, particularly EZH2 (Enhancer of Zeste homolog 2) and EZH2-mediated trimethylation of lysine 27 on histone H3 (H3K27me3). EZH2, which is overexpressed in carcinoma, is also upregulated in psoriatic lesions (Zhang et al., 2020).
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 8Sunscreens: Misconceptions and Misinformation - 9 month(s) ago
Over the past 70 years, sunscreens have evolved from beach products designed to prevent sunburn to more cosmetically elegant skincare products intended to protect against multiple long-term adverse consequences of characteristically low-intensity daily UV and visible light exposure. Sunscreen testing and labeling intended to quantify such protection are unfortunately often misunderstood by users and have also led to illegal misleading and potentially dangerous industry practices. Changes in regulatory requirements, better policing, and more informative sunscreen labeling would benefit users and their physician advisors.
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 0Ruxolitinib Cream in the Treatment of Cutaneous Lichen Planus: A Prospective, Open-Label Study - 9 month(s) ago
Ruxolitinib is a Janus kinase 1/2 inhibitor that blocks signal transduction of interferon-gamma, a critical cytokine involved in the pathogenesis of cutaneous lichen planus (LP). In this prospective phase II study, we investigated the efficacy of topical ruxolitinib in cutaneous LP and performed transcriptomic analysis before and after therapy. Twelve patients with cutaneous LP applied topical ruxolitinib twice daily for 8 weeks. Primary endpoints were changes in total lesion count and changes in modified Composite Assessment of Index Lesion Severity score in index treated and untreated index control lesions at week 4.
Source: www.jidonline.orgCategories: Dermatology, Latest HeadlinesTweet
Neuroanatomic Signatures in Brachioradial Pruritus, Chronic Prurigo, and Atopic Dermatitis https://t.co/T4b6wL52r7 #JIDJournal #dermscience #dermtwitter