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    The Cancer News Daily - 1 year(s) ago

    The latest in cancer medicine and translational research by Wafik El-Deiry MDPhD

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    • The latest The Cancer News Daily! https://t.co/fxtVS3uj8b Thanks to @CathyEngMD @CancerNetwrk @OncLive #esmo2022 #lcsm

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    Julien Maziéres, MD, PhD, explains the importance of defining a second-line standard of care in the EGFR-mutated non–small cell lung cancer population, highlights the long-term benefits seen with tepotinib plus osimertinib, and previews the next steps that should be taken toward more individualized patient care.

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    • Tepotinib plus osimertinib is a promising combination in patients with osimertinib-pretreated, EGFR-mutated, MET amplified non­–small cell lung cancer. @JulienMazieres @myESMO #lcsm #ESMO2022 https://t.co/9qB70fm09t https://t.co/z5ivliFpDI

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    Pembrolizumab plus chemotherapy demonstrated sustained improvements in progression-free survival and overall survival vs placebo plus chemotherapy in patients with treatment-naïve, metastatic squamous non–small cell lung cancer regardless of PD-L1 expression level.

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    • Data from the KEYNOTE-407 trial showed that at a median follow-up of 56.9 months, the median OS was 17.2 months with pembrolizumab vs 11.6 months with placebo. @myESMO #lcsm #ESMO2022 https://t.co/O0A66Zbrlu https://t.co/WQwuAGdA8Q

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    The addition of AZD4635 to durvalumab or oleclumab did not elicit significant responses in heavily pretreated patients with metastatic castration-resistant prostate cancer.

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    • In a phase 2 trial of patients with mCRPC, only 1 objective response was achieved in a patient treated with AZD4635 plus durvalumab, and no responses were achieved in those who received AZD4635 and oleclumab. @columbiacancer @myESMO #pcsm #ESMO2022 https://t.co/05GdvkSmQd https://t.co/Wg8RWAN00O

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    Nageshwara Arvind Dasari, MD, discusses the results of the phase 3 FRESCO-2 trial of fruquintinib in patients with refractory metastatic colorectal cancer, the significance of the data for the treatment paradigm, and the potential next steps for examining the agent in this disease.

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    • .@adasarimd, of @MDAndersonNews, discusses the results of the FRESCO-2 trial of fruquintinib in patients with refractory mCRC, the significance of the data, and the potential next steps for examining the agent in this disease. @myESMO #crcsm #ESMO2022 https://t.co/0vPij9mjMp

  • Mashup Score: 0

    Julien Maziéres, MD, PhD, explains the importance of defining a second-line standard of care in the EGFR-mutated non–small cell lung cancer population, highlights the long-term benefits seen with tepotinib plus osimertinib, and previews the next steps that should be taken toward more individualized patient care.

    Tweet Tweets with this article
    • .@JulienMazieres explains the importance of defining a second-line SOC in EGFR-mutated NSCLC, long-term benefits seen w/ tepotinib & osimertinib, & the next steps that should be taken toward more individualized patient care. @myESMO #lcsm #ESMO2022 https://t.co/eynsNm4JU2