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    From 2005 to 2015, the publication of noninferiority trials increased by six-fold. Noninferiority trials assess whether a new treatment’s efficacy is comparable with that of the standard of care and have several appeals. Noninferiority trials can evaluate for both noninferiority and superiority of a new treatment. In addition, multiple treatment modalities exist, and new treatments may be…

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    Section snippetsDeclaration of competing interestThe authors declare no competing interests related to this article.View full text© 2022 Elsevier Inc. All rights reserved.

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