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Mashup Score: 5
In his discussion of the CHECKMATE 8HW trial, Dr. Tanios Bekaii-Saab examined the efficacy of chemotherapy versus nivolumab plus ipilimumab as the initial treatment for metastatic colorectal cancer with high microsatellite instability and deficient mismatch repair.
Source: www.onclive.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 4
In his discussion of the CHECKMATE 8HW trial, Dr. Tanios Bekaii-Saab examined the efficacy of chemotherapy versus nivolumab plus ipilimumab as the initial treatment for metastatic colorectal cancer with high microsatellite instability and deficient mismatch repair.
Source: www.onclive.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 38HER2 Gene Expression Levels Are Predictive and Prognostic in Patients With Metastatic Colorectal Cancer Enrolled in CALGB/SWOG 80405 - 2 month(s) ago
PURPOSE The phase III Cancer and Leukemia Group B (CALGB)/SWOG 80405 trial found no difference in overall survival (OS) in patients with metastatic colorectal cancer receiving first-line chemotherapy in combination with either bevacizumab or cetuximab. We investigated the potential prognostic and predictive value of HER2 amplification and gene expression using next-generation sequencing (NGS) and NanoString data. PATIENTS AND METHODS Primary tumor DNA from 559 patients was profiled for HER2 amplification by NGS (FoundationOne CDx). Tumor tissue from 925 patients was tested for NanoString gene expression using an 800-gene panel. OS and progression-free survival (PFS) were the time-to-event end points. RESULTS High HER2 expression (dichotomized at median) was associated with longer PFS (11.6 v 10 months, P = .012) and OS (32 v 25.3 months, P = .033), independent of treatment. An OS benefit for cetuximab versus bevacizumab was observed in the high HER2 expression group (P = .02), whereas
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Mashup Score: 27Impact of Helicobacter pylori Infection and Treatment on Colorectal Cancer in a Large, Nationwide Cohort - 2 month(s) ago
PURPOSE Helicobacter pylori is the most common cause of infection-associated cancer worldwide. We aimed to evaluate the impact of H. pylori infection and treatment on colorectal cancer (CRC) incidence and mortality. PATIENTS US Veterans who completed H. pylori testing between 1999 and 2018. METHODS We conducted a retrospective cohort analysis among adults within the Veterans Health Administration who completed testing for H. pylori. The primary exposures were (1) H. pylori test result (positive/negative) and (2) H. pylori treatment (untreated/treated) among H. pylori–positive individuals. The primary outcomes were CRC incidence and mortality. Follow-up started at the first H. pylori testing and continued until the earliest of incident or fatal CRC, non-CRC death, or December 31, 2019. RESULTS Among 812,736 individuals tested for H. pylori, 205,178 (25.2%) tested positive. Being H. pylori–positive versus H. pylori–negative was associated with higher CRC incidence and mortality. H. pylor
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Mashup Score: 7Screening Madness - Big Ten Cancer Research Consortium - 2 month(s) ago
March is Colorectal Cancer Awareness Month. Throughout the month, the Big Ten Cancer Research Consortium and the Blue Hat Foundation are teaming up to increase awareness of the importance of colorectal cancer screening. If you or your loved one are age 45 or older, now is the time to act if you have not… Read More
Source: bigtencrc.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 5
PURPOSE Early-onset colorectal cancer (EOCRC), defined as CRC diagnosed before age 50 years, has increased significantly worldwide. The majority of EOCRCs do not appear to be driven by genetic factors and may be influenced by environmental factors. We hypothesized that sociodemographic disparities exist in EOCRC. The purpose was of the study was to examine the geographic disparities in patients with EOCRC. METHODS We retrospectively examined the SEER database from 1976 to 2016 to examine the geographic disparities in EOCRC. A total of 73,378 patients with EOCRC were included in the analysis. We performed univariate and multivariable analyses to evaluate overall survival (OS) and disease-specific survival (DSS). Sociodemographic factors, including the location of residence (metropolitan areas [MA] or rural areas [RA]), sex, race, insurance status, and marital status, were included in the statistical analysis. RESULTS The incidence and mortality rates were consistently higher in RA versu
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Mashup Score: 2Association of RNF43 Genetic Alterations With BRAFV600E and MSIhigh in Colorectal Cancer - 2 month(s) ago
PURPOSE Recent studies have provided evidence for a predictive value of RNF43 genetic alterations (GAs) as biomarkers for targeted therapies in microsatellite-stable (MSS) colorectal cancer (CRC). These data have the potential to prioritize treatment strategies in patients with BRAFV600E-mutant CRC and help to identify a subgroup that is more likely to derive benefit versus those patients for whom alternative treatment approaches are needed. We were therefore interested in defining the precise frequency of BRAFV600E and RNF43 GAs and their respective overlap in a large cohort of patients with CRC. METHODS To address this question, we performed a retrospective analysis that included 52,969 patients diagnosed with CRC from the FoundationCORE database. RESULTS We observed a striking association of RNF43 GAs with MSI and tumor mutational burden status and BRAFV600E mutations. Overall, 23% of MSS patients with confirmed BRAFV600E mutation harbor an RNF43 GA—which accounts for 1.1% of all pa
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Mashup Score: 2Is ChatGPT Reliable for CRC Screening/Surveillance Advice? - 3 month(s) ago
When put to the test, ChatGPT performed relatively poorly in determining appropriate screening and surveillance recommendations for colorectal cancer.
Source: www.medscape.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Is ChatGPT Reliable for CRC Screening/Surveillance Advice? - 3 month(s) ago
When put to the test, ChatGPT performed relatively poorly in determining appropriate screening and surveillance recommendations for colorectal cancer.
Source: www.medscape.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 6
PURPOSE CALGB (Alliance)/SWOG 80405 was a randomized phase III trial that in first-line patients with metastatic colorectal cancer (mCRC) treated with bevacizumab or cetuximab with chemotherapy. We aimed to discover novel mutated genes associated with prognosis and differential response to therapy with the biologics. METHODS Primary tumor DNA from 548 patients was sequenced using FoundationOne. The effect of mutated genes and mutations on overall survival (OS) was tested adjusting for microsatellite instability status, BRAF V600E, all RAS mutations, arm, sex, and age. RESULTS The median number (lower-upper quartile) of mutated genes was 5 (3-7), 5 (3-6) in microsatellite stable and 12.5 (4.5-32) in microsatellite instability-high tumors. Mutated KRAS and APC were more frequent in Black (53% and 85%) than White (27% and 65%, respectively) patients while BRAF V600E was less frequent in Black (5%) than White (14%) patients. The median OS in patients with BRAF non-V600E (2.2% of patients)
Source: ascopubs.orgCategories: General Medicine News, Onc News and JournalsTweet
Learn more about the CHECKMATE 8HW trial, examining the efficacy of chemotherapy versus nivolumab plus ipilimumab as the initial treatment for metastatic #ColorectalCancer w/ high microsatellite instability and dMMR. @GIcancerDoc @mayoclinic #crcsm https://t.co/vlgCyYwflP