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Mashup Score: 29Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis - 1 month(s) ago
Objective To investigate the risk of cardiovascular disease (CVD) associated with increasing dose of a non-steroidal anti-inflammatory drug (NSAID) in patients with ankylosing spondylitis (AS). Methods Using the Korean National Health Insurance database, patients newly diagnosed with AS without prior CVD between 2010 and 2018 were included in this nationwide cohort study. The primary outcome was CVD, a composite outcome of ischaemic heart disease, stroke or congestive heart failure. Exposure to NSAIDs was evaluated using a time-varying approach. The dose of NSAIDs was considered in each exposure period. Cox proportional hazard regression was used to investigate the risk of CVD associated with NSAID use. Results Of the 19â775 patients (mean age, 36 years; 75% were male), 19â706 received NSAID treatment. During follow-up period of 98â290 person-years, 1663 cases of CVD occurred including 1157 cases of ischaemic heart disease, 301 cases of stroke and 613 cases of congestive heart failure.
Source: ard.bmj.comCategories: General Medicine News, RheumatologyTweet
ð€ What is worse for #cardiovascular disease in ankylosing #spondylitis- continuous low or intermittent high #NSAIDs? ð· 19706 Korean patients studied ð¶ higher dose of NSAID treatment was associated with a higher risk of CVDâ https://t.co/oAh6X79TWr https://t.co/6kC0xVVwND