Cardiac amyloidosis is becoming increasingly recognized as an etiology for heart failure (HF). Most cases of amyloid cardiomyopathy will fall into one of two categories: light-chain amyloid (AL) amyloidosis resulting from misfolding of monoclonal immunoglobulin light chains or transthyretin amyloidosis with cardiomyopathy (ATTR-CM), due to misfolding of the transthyretin protein. 1 The rise of newer imaging techniques over the last few years have allowed for accurate noninvasive diagnosis of ATTR-CM.

The idea that obesity increases the risk of heart failure seems like an obvious conclusion. After all, as the Framingham Heart Study clearly showed, obesity and overweight are significantly associated with a higher risk of hypertension, angina and coronary heart disease. 1 In addition, up to 80% of people with the most common form of the condition, heart failure with preserved ejection fraction (HFpEF), have overweight or obesity. 2-4 Yet for decades, says Mikhail Kosiborod, MD, FACC, who co-directs the