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Mashup Score: 17Diurnal production of cortisol and prediction of treatment response in rheumatoid arthritis: a 6-month, real-life prospective cohort study - 3 month(s) ago
Objectives A reduced adrenal reserve-associated cortisol production relative to the enhanced needs of chronic inflammation ( disproportion principle ) has been observed in rheumatoid arthritis (RA). We examined the possible clinical value of diurnal cortisol measurements in active RA on treatment response prediction. Methods Diurnal cortisol production (measured at: 08–12:00/18:00–22:00) was assessed by electrochemiluminescence immunoassay in 28 consecutive patients with moderately/highly active RA, as well as 3 and 6 months after treatment initiation or/escalation. Twenty-eight COVID-19 patients and 28 age-matched healthy individuals (HC) served as controls. Results Saliva diurnal cortisol production in patients with RA was similar to that of HC, despite 12-fold higher serum C reactive protein (CRP) levels, and lower than COVID-19 patients (area under the curve: RA: 87.0±37.6 vs COVID-19: 146.7±14.3, p<0.001), having similarly high CRP. Moreover, a disturbed circadian cortisol rhythm
Source: rmdopen.bmj.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 34
Objectives To compare the effectiveness of longstanding (>52 weeks), supervised exercise therapy with usual care in adults with rheumatoid arthritis (RA) and severe functional limitations. Methods Participants were randomised 1:1 to the intervention (individualised goal-setting, active exercises, education and self-management regarding physical activity) or usual care. Primary endpoint was the change in the Patient-Specific Complaints activity ranked 1 (PSC1, 0–10) at 52 weeks. Secondary endpoints included the PSC activities ranked 2 and 3 (PSC2, PSC3), Health Assessment Questionnaire-Disability Index (HAQ-DI), Rheumatoid Arthritis Quality of Life Questionnaire (RAQoL), 6-minute walk test (6MWT), Patient Reported Outcome Measurement Information System Physical Function-10 (PROMIS PF-10) and the Short Form-36 Physical and Mental Component Summary Scales (SF-36 PCS and MCS). (Serious) Adverse events (AEs) were recorded. Measurements were done by blinded assessors. Analyses at 52 weeks we
Source: ard.bmj.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 23When does obesity exert its effect in conferring risk of developing RA: a large study in cohorts of symptomatic persons at risk - 3 month(s) ago
Objectives Obesity is a known risk factor for developing rheumatoid arthritis (RA). However, it is unclear whether obesity exerts its risk effect during the asymptomatic or the symptomatic clinically suspect arthralgia (CSA) phase of risk. To improve understanding of the effect of obesity on RA development, we aimed to (1) compare body mass index (BMI) at CSA onset to BMI of the general population and (2) study within CSA patients if obesity increases the risk for progression to RA. Methods 1107 symptomatic persons at risk for RA from four cohorts (CSA Leiden, CSA Rotterdam, SONAR and TREAT EARLIER placebo arm) were studied. For the first aim, baseline BMI was compared with age-matched/sex-matched BMI of the general population. Patients were stratified for anticitrullinated protein antibody (ACPA) status. Regarding the second aim, the association between BMI and inflammatory arthritis (IA) development during 2 years was studied with Cox regression analysis within each cohort and via me
Source: rmdopen.bmj.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 43Therapeutic advances in rheumatoid arthritis - 3 month(s) ago
Rheumatoid arthritis (RA) is one of the most common immune mediated inflammatory diseases. People with rheumatoid arthritis present with pain, swelling, and stiffness that typically affects symmetrically distributed small and large joints. Without effective treatment, significant joint damage, disability, and work loss develop, owing to chronic inflammation of the joint lining (synovium). Over the past 25 years, the management of this condition has been revolutionized, resulting in substantially higher levels of disease remission and better long term outcomes. This improvement reflects a paradigm shift towards early and aggressive pharmacological intervention coupled with a proliferation in treatment choice, in turn related to enhanced pathobiological understanding and the advent of new drugs for rheumatoid arthritis. Following an overview of these developments from a historical perspective, and with a general audience in mind, this review focuses on newer, targeted treatments in an ev
Source: www.bmj.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 4Tool Uses Genetics to Diagnose Early Inflammatory Arthritis - 4 month(s) ago
The tool may aid in accelerating accurate diagnosis and getting patients on the right treatments earlier.
Source: www.medscape.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0
The PETRA questionnaire proves valuable in assessing the transition readiness of juvenile idiopathic arthritis patients into adult care, with a focus on self-management skills.
Source: www.hcplive.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Home - 4 month(s) ago
In this live webinar, expert faculty will discuss the pathophysiologic changes and the role of the innate and adaptive immunity throughout the course of different forms of arthritis, including autoinflammatory diseases. This webinar will also cover the “window of opportunity” and “joint-specific memory” and their implications on the current treatment strategies to optimize outcomes in patients with arthritis and autoinflammatory diseases. This activity is intended for a European audience of primary care
Source: na.eventscloud.comCategories: General Medicine News, DermatologyTweet
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Mashup Score: 0
The PETRA questionnaire proves valuable in assessing the transition readiness of juvenile idiopathic arthritis patients into adult care, with a focus on self-management skills.
Source: www.hcplive.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 15Research Team - Arthritis Research Canada - 4 month(s) ago
The scientific team at Arthritis Research Canada is focused on understanding, advancing and sharing knowledge about the causes of arthritis and addressing the issues that impact the lives of people living with this disease. With more than 100 research scientists and staff at facilities in British Columbia, Alberta, Quebec, and Nova Scotia, our multi-disciplinary team is dedicated to leading…
Source: www.arthritisresearch.caCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 16Arthritis Research Education Series - Self-Care - Resources - Arthritis Research Canada - 5 month(s) ago
Discover frequently asked questions, videos and other resources about self-care to help people take control of life, despite arthritis.
Source: www.arthritisresearch.caCategories: General Medicine News, RheumatologyTweet
Can altered circadian rhythm of cortisol influence treatment response in #arthritis? ▶️ no differences in diurnal cortisol production between RA and controls ▶️ not achieving minimal disease activity linked to lower morning cortisol and higher ACTH 🔗 https://t.co/a1EjrFCRGD https://t.co/NP0eLWFW16